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Cplx1 complexin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64832, updated on 2-Oct-2021

Summary

Official Symbol
Cplx1provided by RGD
Official Full Name
complexin 1provided by RGD
Primary source
RGD:70944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
binds the assembled SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) complex; modulates synaptic vesicle exocytosis [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 725.8) See more
Orthologs
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Genomic context

See Cplx1 in Genome Data Viewer
Location:
14p22
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (1184638..1216392)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (2194895..2226610)

Chromosome 14 - NC_051349.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 175 Neighboring gene cyclin G associated kinase Neighboring gene U6 spliceosomal RNA Neighboring gene polycomb group ring finger 3 Neighboring gene solute carrier family 49 member 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
enables neurotransmitter transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables syntaxin-1 binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in terminal bouton HDA PubMed 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
complexin-1
Names
CPX I
complexin I
synaphin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022864.4NP_074055.1  complexin-1

    See identical proteins and their annotated locations for NP_074055.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000247
    UniProtKB/Swiss-Prot
    P63041
    Conserved Domains (1) summary
    pfam05835
    Location:1133
    Synaphin; Synaphin protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051349.1 Reference mRatBN7.2 Primary Assembly

    Range
    1184638..1216392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250571.4XP_006250633.1  complexin-1 isoform X1

    UniProtKB/Swiss-Prot
    P63041
    Conserved Domains (1) summary
    pfam05835
    Location:1133
    Synaphin; Synaphin protein
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