Mertk MER proto-oncogene, tyrosine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mertkprovided by RGD
Official Full Name: MER proto-oncogene, tyrosine kinaseprovided by RGD
Primary source: RGD:69283
See related: Ensembl:ENSRNOG00000017319 AllianceGenome:RGD:69283
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rdy
Summary: Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in phagocytosis; positive regulation of phagocytosis; and protein phosphorylation. Located in photoreceptor outer segment. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in retinitis pigmentosa 38. Orthologous to human MERTK (MER proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 144.3), Spleen (RPKM 123.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (136391936..136498366)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (115939351..116045141)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (121235230..121340932)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study of the Role of the Tyrosine Kinase Receptor MerTK in the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats.
Title: Study of the Role of the Tyrosine Kinase Receptor MerTK in the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats.
Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK.
Title: Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK.
The long-term preservation of photoreceptors we observed indicates that MERTK-related form of inherited retinal degeneration, which has currently no cure, could be amenable to laser therapy or subretinal surgery, to extend the visual function, potentially for life.
Title: Long-term Rescue of Photoreceptors in a Rodent Model of Retinitis Pigmentosa Associated with MERTK Mutation.
Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans. We present here a comprehensive review of all reported MERTK disease causing variants with the associated phenotype
Title: MERTK mutation update in inherited retinal diseases.
Mertk protein expression in the Bone marrow mesenchymal stem cells was similar to that in the retinal pigment epithelial cells in the primary passage.
Title: Mertk gene expression and photoreceptor outer segment phagocytosis by cultured rat bone marrow mesenchymal stem cells.
study concludes that activated microglia release Gal-3 and a neuraminidase that desialylates microglial and PC12 surfaces, enabling Gal-3 binding to PC12 (neuron-like) cells and their phagocytosis via Mer tyrosine kinase (MerTK).
Title: Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase.
This study demonstrated that in Mertk mutation mice regulated the Expression pattern of Ccr2 and Cx3cr1.
Title: Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration.
A novel role of MERTK signaling in membrane trafficking in the Retinal Pigment Eepithelium that is likely to subserve mechanisms of phagosome formation.
Title: MERTK signaling in the retinal pigment epithelium regulates the tyrosine phosphorylation of GDP dissociation inhibitor alpha from the GDI/CHM family of RAB GTPase effectors.
A deletion in the Mer tyrosine kinase (MerTK) receptor in Royal College of Surgeons rat that abolishes internalization of photoreceptor outer segments by retinal pigment epithelial cells.
Title: Mertk in daily retinal phagocytosis: a history in the making.
Key involvement of mer in outer segment phsgocytosis has been clearly proven.
Title: The phagocytosis of os is mediated by the PI3-kinase linked tyrosine kinase receptor, mer, and is stimulated by GAS6.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048840 (e-PCR)
- UniSTS:145290

MERTK (e-PCR)
- UniSTS:505021

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
involved_in apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of lymphocyte activation	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of leukocyte apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of lymphocyte activation	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil clearance	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within secretion by cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vagina development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase Mer

Names: Receptor tyrosine tinase gene probably the gene for Rdy; c-mer proto-oncogene tyrosine kinase; proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; receptor tyrosine kinase MerTK; retinal dystrophy

NP_075232.1

EC 2.7.10.1

XP_063140597.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022943.1 → NP_075232.1 tyrosine-protein kinase Mer precursor

See identical proteins and their annotated locations for NP_075232.1

Status: PROVISIONAL

Source sequence(s)

AF208235

UniProtKB/Swiss-Prot

P57097

UniProtKB/TrEMBL

A0A8I5ZYY3, A6HQ37

Related

ENSRNOP00000076826.1, ENSRNOT00000097978.1

Conserved Domains (6) summary

cd05749
Location:194 → 274

Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)

smart00410
Location:95 → 188

IG_like; Immunoglobulin like

cd00063
Location:279 → 373

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14204
Location:574 → 857

PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer

pfam00047
Location:97 → 171

ig; Immunoglobulin domain

pfam07714
Location:582 → 849

Pkinase_Tyr; Protein tyrosine kinase