Arl6ip5 ADP-ribosylation factor-like 6 interacting protein 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arl6ip5provided by MGI
Official Full Name: ADP-ribosylation factor-like 6 interacting protein 5provided by MGI
Primary source: MGI:MGI:1929501
See related: Ensembl:ENSMUSG00000035199 AllianceGenome:MGI:1929501
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aip-5; addiscin; Gtrap3-18; 5930404D22Rik
Summary: Predicted to enable protein C-terminus binding activity. Involved in negative regulation of L-glutamate import across plasma membrane. Acts upstream of or within with a negative effect on L-glutamate import across plasma membrane and protein localization to plasma membrane. Acts upstream of or within several processes, including L-glutamate transmembrane transport; glutathione metabolic process; and neuron death in response to oxidative stress. Located in plasma membrane. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human ARL6IP5 (ADP ribosylation factor like GTPase 6 interacting protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 60.0), CNS E18 (RPKM 49.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D3; 6 44.91 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (97187753..97210276)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (97210792..97233315)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glutamate transporter-associated protein 3-18 (GTRAP3-18), an anchor protein that retains interacting proteins in the endoplasmic reticulum, is a critical regulator of food intake and body weight by interacting with POMC. GTRAP3-18-deficient mice showed hypophagia, lean bodies, and lower blood glucose, insulin, and leptin levels with increased serum and brain alpha-MSH levels, leading to AMPK inhibition.
Title: GTRAP3-18 regulates food intake and body weight by interacting with pro-opiomelanocortin.
Protective effect of JWA against paraquat neurotoxicity involves regulation of the MEK/PI3K-Nrf2 axis.
Title: JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2.
the JWA deficiency through cascading FAK-PI3K-Akt-mTOR pathway increases the newborn neurons.
Title: Lack of JWA Enhances Neurogenesis and Long-Term Potentiation in Hippocampal Dentate Gyrus Leading to Spatial Cognitive Potentiation.
These findings indicated that Arl6ip5 was an anti-catabolic factor by binding with RANKL and disturbing its subcellular trafficking in osteoblast.
Title: Overexpression of Arl6ip5 in osteoblast regulates RANKL subcellualr localization.
Arl6ip5 is a novel regulator of bone formation in osteoblasts.
Title: Deficiency of osteoblastic Arl6ip5 impaired osteoblast differentiation and enhanced osteoclastogenesis via disturbance of ER calcium homeostasis and induction of ER stress-mediated apoptosis.
This study provided evidence that astrocytic JWA expression protects DA neurons from degeneration and plays an important role in neuroprotection via inhibition of ROS and NF-kappaB activation.
Title: Astrocytic JWA expression is essential to dopaminergic neuron survival in the pathogenesis of Parkinson's disease.
The double-fluorescent immunohistochemical analysis revealed that addicsin and TR1 were coexpressed in neurons
Title: Identification of tomoregulin-1 as a novel addicsin-associated factor.
Data show the importance of JWA (Arl6ip5) in skin homeostasis and in the process of skin tumor development.
Title: JWA deficiency suppresses dimethylbenz[a]anthracene-phorbol ester induced skin papillomas via inactivation of MAPK pathway in mice.
This study demonistrated that GTRAP3-18(-/-) mice performed better in motor/spatial learning and memory tests. The suppression of GTRAP3-18 increases neuronal resistance to oxidative stress by increasing GSH content and also facilitates cognitive function
Title: Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice.
Arl6ip1 is a novel addicsin-associated partner that promotes EAAC1-mediated glutamate transport activity by decreasing the number of addicsin molecules available for interaction with EAAC1.
Title: Modulation of the neural glutamate transporter EAAC1 by the addicsin-interacting protein ARL6IP1.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within_negative_effect L-glutamate import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glutathione metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of L-glutamate import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of neurotransmitter uptake	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PRA1 family protein 3

Names: ADP-ribosylation factor-like protein 6-interacting protein 5; ADP-ribosylation-like factor 6 interacting protein 5; ARL-6-interacting protein 5; addicsin; glutamate transporter EAAC1-interacting protein; prenylated Rab acceptor protein 2; protein JWa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.