Rida reactive intermediate imine deaminase A homolog [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ridaprovided by RGD
Official Full Name: reactive intermediate imine deaminase A homologprovided by RGD
Primary source: RGD:70940
See related: AllianceGenome:RGD:70940
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Psp; PSP1; L-PSP; Hrsp12; rp14.5
Summary: Enables several functions, including endoribonuclease activity, producing 3'-phosphomonoesters; identical protein binding activity; and long-chain fatty acid binding activity. Involved in several processes, including G1 to G0 transition; animal organ development; and negative regulation of translation. Located in several cellular components, including cytosol; mitochondrial matrix; and peroxisome. Orthologous to human RIDA (reactive intermediate imine deaminase A homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 11218.5), Liver (RPKM 6497.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (67576586..67590493, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (65691429..65705257, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (73256506..73270308, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These studies define new roles for glucocorticoid receptor, Y-box binding protein 1, and RNase UK114 in the formation of a molecular complex that degrades MCP-1 mRNA.
Title: Y-box binding protein 1 and RNase UK114 mediate monocyte chemoattractant protein 1 mRNA stability in vascular smooth muscle cells.
Intestinal PSP expression was induced by approximately 3-fold by oral administration of dietary fat
Title: Perchloric acid-soluble protein is expressed in enterocytes and goblet cells in the intestine and upregulated by dietary lipid.
Expression of PSP protein and mRNA decreased and then gradually increased during liver regeneration
Title: Reduced expression of perchloric acid-soluble protein after partial hepatectomy in rats.
PSP is involved in the cellular response to ER stressors, and that the change in localization of PSP from the endoplasmic reticulum to the nucleus may be associated with endoplasmic reticulum stress responses.
Title: Nuclear transfer of perchloric acid-soluble protein by endoplasmic reticulum stressors.
first report on the presence of perchloric acid soluble protein (PSP)in rat lung and on its involvement in the regulation of cellular growth and differentiation [Hrsp12].
Title: Purification and characterization of perchloric acid soluble protein from rat lung.
expression of perchloric acid-soluble protein PSP in rat hepatoma was down regulated as compared with intact tissue.
Title: Down regulation of a novel protein, PSP, in rat hepatoma cdRLh 84-beared tumor.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2-iminobutanoate deaminase activity	IEA Inferred from Electronic Annotation more info
enables 2-iminobutanoate deaminase activity	ISO Inferred from Sequence Orthology more info
enables 2-iminobutanoate deaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 2-iminopropanoate deaminase activity	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity, producing 3'-phosphomonoesters	IDA Inferred from Direct Assay more info	PubMed
enables cation binding	IDA Inferred from Direct Assay more info	PubMed
enables deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables long-chain fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables transition metal ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G1 to G0 transition	IEP Inferred from Expression Pattern more info	PubMed
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA destabilization	IEA Inferred from Electronic Annotation more info
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in organonitrogen compound catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 2-iminobutanoate/2-iminopropanoate deaminase

Names: 14.5 kDa translational inhibitor protein; UK114 antigen homolog; heat-responsive protein 12; liver perchloric acid-soluble protein; perchloric acid-soluble protein; perchrolic acid soluble protein; ribonuclease UK114; translation inhibitor L-PSP ribonuclease

NP_113902.2

EC 3.5.99.10

XP_063120287.1

EC 3.5.99.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031714.2 → NP_113902.2 2-iminobutanoate/2-iminopropanoate deaminase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

O35262, P52759, Q9WUV8

UniProtKB/TrEMBL

A6HR02

Conserved Domains (1) summary

TIGR00004
Location:6 → 129

TIGR00004; reactive intermediate/imine deaminase