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Dpysl5 dihydropyrimidinase-like 5 [ Mus musculus (house mouse) ]

Gene ID: 65254, updated on 6-May-2021

Summary

Official Symbol
Dpysl5provided by MGI
Official Full Name
dihydropyrimidinase-like 5provided by MGI
Primary source
MGI:MGI:1929772
See related
Ensembl:ENSMUSG00000029168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CR; Crm; CRAM; CRMP; Crmp5; CRMP-5
Expression
Biased expression in CNS E18 (RPKM 113.7), whole brain E14.5 (RPKM 105.1) and 6 other tissues See more
Orthologs
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Genomic context

See Dpysl5 in Genome Data Viewer
Location:
5; 5 B1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30868908..30956713)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30711564..30799369)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (31014268..31101742)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene autophagy-related 3 pseudogene Neighboring gene predicted gene, 46907 Neighboring gene microtubule-associated protein, RP/EB family, member 3 Neighboring gene transmembrane protein 214

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables dihydropyrimidinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance TAS
Traceable Author Statement
more info
PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in pyrimidine nucleobase catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IPI
Inferred from Physical Interaction
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dihydropyrimidinase-related protein 5
Names
DRP-5
collapsin response mediator protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356948.1NP_001343877.1  dihydropyrimidinase-related protein 5 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC105298, AC109611
    Consensus CDS
    CCDS39047.1
    Related
    ENSMUSP00000110377.2, ENSMUST00000114729.8
    Conserved Domains (1) summary
    cd01314
    Location:10459
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
  2. NM_001356949.1NP_001343878.1  dihydropyrimidinase-related protein 5 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC105298, BC103789
    Consensus CDS
    CCDS89896.1
    Related
    ENSMUSP00000098985.4, ENSMUST00000101442.4
    Conserved Domains (1) summary
    cl00281
    Location:1087
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
  3. NM_023047.3NP_075534.1  dihydropyrimidinase-related protein 5 isoform a

    See identical proteins and their annotated locations for NP_075534.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC105298, BC065054
    Consensus CDS
    CCDS39047.1
    UniProtKB/Swiss-Prot
    Q9EQF6
    Related
    ENSMUSP00000085400.5, ENSMUST00000088081.11
    Conserved Domains (1) summary
    cd01314
    Location:10459
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    30868908..30956713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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