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Cd99 CD99 molecule (Xg blood group) [ Rattus norvegicus (Norway rat) ]

Gene ID: 652929, updated on 11-Apr-2024

Summary

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Official Symbol
Cd99provided by RGD
Official Full Name
CD99 molecule (Xg blood group)provided by RGD
Primary source
RGD:1594332
See related
AllianceGenome:RGD:1594332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in T cell extravasation; homotypic cell-cell adhesion; and positive regulation of neutrophil extravasation. Predicted to act upstream of or within myeloid dendritic cell activation. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Orthologous to human CD99 (CD99 molecule (Xg blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 301.4), Kidney (RPKM 234.9) and 9 other tissues See more
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Genomic context

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Location:
20q13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (56000494..56005140, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (54418239..54422882, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (56192426..56196961, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556677 Neighboring gene uncharacterized LOC103694460 Neighboring gene dehydrogenase/reductase X-linked like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rapid divergency of rodent CD99 orthologs: implications for the evolution of the pseudoautosomal region. Park SH, et al. Gene, 2005 Jul 4. PMID 15978751
  2. Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. Shiratori I, et al. J Exp Med, 2004 Feb 16. PMID 14970179, Free PMC Article
  3. A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo. Bixel MG, et al. Blood, 2007 Jun 15. PMID 17344467
  4. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in T cell extravasation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within T cell extravasation ISO
Inferred from Sequence Orthology
more info
  
involved_in homotypic cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within homotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myeloid dendritic cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neutrophil extravasation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of neutrophil extravasation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CD99 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100804.1 → NP_001094274.1  CD99 antigen precursor

    See identical proteins and their annotated locations for NP_001094274.1

    Status: VALIDATED

    Source sequence(s)
    AY262357, BC168196
    UniProtKB/TrEMBL
    B4F7A5, Q4L2A2
    Conserved Domains (1) summary
    pfam12301
    Location:52 → 163
    CD99L2; CD99 antigen like protein 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    56000494..56005140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099057.2 → XP_038954985.1  CD99 antigen isoform X3

    Conserved Domains (1) summary
    pfam12301
    Location:25 → 134
    CD99L2; CD99 antigen like protein 2

  2. XM_039099056.2 → XP_038954984.1  CD99 antigen isoform X2

    UniProtKB/TrEMBL
    A6K6T0, Q4L2A2

  3. XM_063279500.1 → XP_063135570.1  CD99 antigen isoform X1

  4. XM_063279502.1 → XP_063135572.1  CD99 antigen isoform X5

  5. XM_063279501.1 → XP_063135571.1  CD99 antigen isoform X4

    UniProtKB/TrEMBL
    A6K6T1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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