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br broad [ Tribolium castaneum (red flour beetle) ]

Gene ID: 659193, updated on 15-Apr-2024

Summary

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Gene symbol
br
Gene description
broad
Locus tag
TcasGA2_TC005474
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Tribolium castaneum
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium
Also known as
Br-c; br-Z2; br-NZ2
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Genomic context

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Location:
chromosome: 6
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_04 current icTriCast1.1 (GCF_031307605.1) 6 NC_087399.1 (2223027..2250766)
103 previous assembly Tcas5.2 (GCF_000002335.3) Linkage Group LG8 NC_007423.3 (12513052..12537648, complement)

Chromosome 6 - NC_087399.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene uncharacterized LOC103314105 Neighboring gene uncharacterized LOC107398541 Neighboring gene Autophagy-related 1 Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 9 Neighboring gene pupal cuticle protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Broad-Complex acts downstream of Met in juvenile hormone signaling to coordinate primitive holometabolan metamorphosis. Konopova B, et al. Development, 2008 Feb. PMID 18171683
  2. Transcription factor broad suppresses precocious development of adult structures during larval-pupal metamorphosis in the red flour beetle, Tribolium castaneum. Parthasarathy R, et al. Mech Dev, 2008 Mar-Apr. PMID 18083350, Free PMC Article
  3. Krüppel homolog 1, an early juvenile hormone-response gene downstream of Methoprene-tolerant, mediates its anti-metamorphic action in the red flour beetle Tribolium castaneum. Minakuchi C, et al. Dev Biol, 2009 Jan 15. PMID 19013451
  4. The Fruitless gene in Nasonia displays complex sex-specific splicing and contains new zinc finger domains. Bertossa RC, et al. Mol Biol Evol, 2009 Jul. PMID 19349644
  5. BeetleBase in 2010: revisions to provide comprehensive genomic information for Tribolium castaneum. Kim HS, et al. Nucleic Acids Res, 2010 Jan. PMID 19820115, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. longitudinals lacking (lola), tramtrack (ttk), broad complex (br), and fruitless (fru) are BTB-C2H2 zinc finger proteins conserved in different insects
    Title: The Fruitless gene in Nasonia displays complex sex-specific splicing and contains new zinc finger domains.
  2. The expression of Tcbr during the final instar larval stage promotes pupal program while suppressing the larval and adult programs ensuring a transitory pupal stage in holometabolous insects.
    Title: Transcription factor broad suppresses precocious development of adult structures during larval-pupal metamorphosis in the red flour beetle, Tribolium castaneum.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
broad-complex
Names
AUGUSTUS-3.0.2_05474
AUGUSTUS-3.0.2_05476
AUGUSTUS-3.0.2_34153
GLEAN_05474
GLEAN_05475

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111264.1 → NP_001104734.1  broad-complex

    See identical proteins and their annotated locations for NP_001104734.1

    Status: PROVISIONAL

    Source sequence(s)
    EU200752
    UniProtKB/TrEMBL
    A8W901, B5U9F8
    Conserved Domains (4) summary
    smart00225
    Location:33 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:400 → 421
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 118
    BTB; BTB/POZ domain
    pfam12756
    Location:400 → 446
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)

RefSeqs of Annotated Genomes: GCF_031307605.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference icTriCast1.1 Primary Assembly

Genomic

  1. NC_087399.1 Reference icTriCast1.1 Primary Assembly

    Range
    2223027..2250766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008199004.3 → XP_008197226.2  broad-complex isoform X1

  2. XM_008199006.3 → XP_008197228.2  broad-complex isoform X1

  3. XM_015982824.2 → XP_015838310.2  broad-complex isoform X3

  4. XM_008199003.3 → XP_008197225.2  broad-complex isoform X1

  5. XM_008199010.3 → XP_008197232.2  broad-complex isoform X6

  6. XM_008199007.3 → XP_008197229.2  broad-complex isoform X2

  7. XM_008199011.3 → XP_008197233.2  broad-complex isoform X7

  8. XM_008199008.3 → XP_008197230.2  broad-complex isoform X4

  9. XM_008199013.3 → XP_008197235.2  broad-complex isoform X8

  10. XM_008199009.3 → XP_008197231.2  broad-complex isoform X5

  11. XM_008199005.3 → XP_008197227.2  broad-complex isoform X1

RNA

  1. XR_010334490.1 RNA Sequence

  2. XR_010334492.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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