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Cubn cubilin (intrinsic factor-cobalamin receptor) [ Mus musculus (house mouse) ]

Gene ID: 65969, updated on 23-Jun-2021

Summary

Official Symbol
Cubnprovided by MGI
Official Full Name
cubilin (intrinsic factor-cobalamin receptor)provided by MGI
Primary source
MGI:MGI:1931256
See related
Ensembl:ENSMUSG00000026726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D2Wsu88; AA408369; AL022750; D2Wsu88e
Expression
Biased expression in placenta adult (RPKM 57.5), kidney adult (RPKM 23.7) and 2 other tissues See more
Orthologs
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Genomic context

See Cubn in Genome Data Viewer
Location:
2 A1; 2 9.86 cM
Exon count:
67
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (13281149..13496687, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (13276338..13491876, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (13197965..13413503, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phosphotriesterase related Neighboring gene C1q-like 3 Neighboring gene Ras suppressor protein 1 Neighboring gene predicted gene 13270 Neighboring gene uncharacterized LOC115489436 Neighboring gene tRNA aspartic acid methyltransferase 1 Neighboring gene predicted gene, 54102

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables cargo receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables cobalamin binding IEA
Inferred from Electronic Annotation
more info
 
enables hemoglobin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi-associated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
located_in coated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal lumen ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cubilin
Names
intrinsic factor-cobalamin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081084.2NP_001074553.1  cubilin precursor

    See identical proteins and their annotated locations for NP_001074553.1

    Status: VALIDATED

    Source sequence(s)
    AF197159, AK141391, AL773538, AL928807, CF165743, CF169457, CK390258, CK391058, CK391475, CK391977, CK623807
    Consensus CDS
    CCDS38048.1
    UniProtKB/Swiss-Prot
    Q9JLB4
    Related
    ENSMUSP00000089009.6, ENSMUST00000091436.7
    Conserved Domains (4) summary
    smart00179
    Location:260301
    EGF_CA; Calcium-binding EGF-like domain
    cd00041
    Location:26892800
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00054
    Location:432468
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam12947
    Location:306344
    EGF_3; EGF domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    13281149..13496687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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