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ZSCAN18 zinc finger and SCAN domain containing 18 [ Homo sapiens (human) ]

Gene ID: 65982, updated on 5-Mar-2024

Summary

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Official Symbol
ZSCAN18provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 18provided by HGNC
Primary source
HGNC:HGNC:21037
See related
Ensembl:ENSG00000121413 AllianceGenome:HGNC:21037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF447
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 14.7), endometrium (RPKM 11.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See ZSCAN18 in Genome Data Viewer
Location:
19q13.43
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58083842..58118426, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61180644..61214896, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58595209..58629793, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 135 Neighboring gene RNA, 7SL, cytoplasmic 526, pseudogene Neighboring gene zinc finger protein 329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15178 Neighboring gene uncharacterized LOC124904784

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Zinc finger and SCAN domain-containing protein 18 is a potential DNA methylation-modified tumor suppressor and biomarker in breast cancer. Wang Y, et al. Front Endocrinol (Lausanne), 2023. PMID 37223020, Free PMC Article
  2. Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cells. Li B, et al. Clin Epigenetics, 2023 Jan 17. PMID 36650573, Free PMC Article
  3. The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers. Vedeld HM, et al. Int J Cancer, 2015 Feb 15. PMID 24948044, Free PMC Article
  4. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article
  5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zinc finger and SCAN domain-containing protein 18 is a potential DNA methylation-modified tumor suppressor and biomarker in breast cancer.
    Title: Zinc finger and SCAN domain-containing protein 18 is a potential DNA methylation-modified tumor suppressor and biomarker in breast cancer.
  2. Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cells.
    Title: Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cells.
  3. A high negative correlation between promoter DNA methylation and gene expression was observed for CDO1, ZNF331 and ZSCAN18 in gastrointestinal tumors.
    Title: The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2427, MGC4074, MGC8682, FLJ12895, FLJ38919, FLJ44152, DKFZp586B1122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and SCAN domain-containing protein 18
Names
zinc finger protein 447

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145542.1 → NP_001139014.1  zinc finger and SCAN domain-containing protein 18 isoform 1

    See identical proteins and their annotated locations for NP_001139014.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AK294376, BC006205, DC354023
    Consensus CDS
    CCDS46214.1
    UniProtKB/Swiss-Prot
    Q8TBC5
    Related
    ENSP00000470123.1, ENST00000600404.1
    Conserved Domains (3) summary
    smart00349
    Location:284 → 321
    KRAB; krueppel associated box
    sd00017
    Location:471 → 491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:102 → 189
    SCAN; SCAN domain

  2. NM_001145543.2 → NP_001139015.1  zinc finger and SCAN domain-containing protein 18 isoform 3

    See identical proteins and their annotated locations for NP_001139015.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different segment for its 5' UTR and lacks a coding region segment, which results in the use of a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same protein (isoform 3), which is shorter when it is compared to isoform 1.
    Source sequence(s)
    AY280799, BC006205
    Consensus CDS
    CCDS12971.1
    UniProtKB/Swiss-Prot
    B4DG23, E9PBI0, Q8TBC5, Q9BRK7, Q9H9A0
    Related
    ENSP00000468934.1, ENST00000601144.6
    Conserved Domains (3) summary
    smart00349
    Location:228 → 265
    KRAB; krueppel associated box
    sd00017
    Location:415 → 435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:46 → 133
    SCAN; SCAN domain

  3. NM_001145544.2 → NP_001139016.1  zinc finger and SCAN domain-containing protein 18 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR and lacks a coding region segment, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    BC006205, BG036776, DA611622
    Consensus CDS
    CCDS46215.1
    UniProtKB/TrEMBL
    A0A0C4DG78
    Related
    ENSP00000392653.1, ENST00000421612.6
    Conserved Domains (2) summary
    smart00349
    Location:93 → 130
    KRAB; krueppel associated box
    sd00017
    Location:279 → 299
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_023926.5 → NP_076415.3  zinc finger and SCAN domain-containing protein 18 isoform 3

    See identical proteins and their annotated locations for NP_076415.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different segment for its 5' UTR and lacks a coding region segment, which results in the use of a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same protein (isoform 3), which is shorter when it is compared to isoform 1.
    Source sequence(s)
    BC006205, BC022846, BG036776
    Consensus CDS
    CCDS12971.1
    UniProtKB/Swiss-Prot
    B4DG23, E9PBI0, Q8TBC5, Q9BRK7, Q9H9A0
    Related
    ENSP00000240727.5, ENST00000240727.10
    Conserved Domains (3) summary
    smart00349
    Location:228 → 265
    KRAB; krueppel associated box
    sd00017
    Location:415 → 435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:46 → 133
    SCAN; SCAN domain

RNA

  1. NR_027135.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents transcription from an upstream promoter and shares the first exon with variant 1. This two-exon transcript includes a different terminal exon but the predicted protein is not represented because there is uncertainty about the protein-coding capacity of the transcript.
    Source sequence(s)
    AC008751
    Related
    ENST00000595944.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58083842..58118426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527239.4 → XP_011525541.1  zinc finger and SCAN domain-containing protein 18 isoform X2

    See identical proteins and their annotated locations for XP_011525541.1

    UniProtKB/Swiss-Prot
    B4DG23, E9PBI0, Q8TBC5, Q9BRK7, Q9H9A0
    Conserved Domains (3) summary
    smart00349
    Location:228 → 265
    KRAB; krueppel associated box
    sd00017
    Location:415 → 435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:46 → 133
    SCAN; SCAN domain

  2. XM_006723335.3 → XP_006723398.1  zinc finger and SCAN domain-containing protein 18 isoform X2

    See identical proteins and their annotated locations for XP_006723398.1

    UniProtKB/Swiss-Prot
    B4DG23, E9PBI0, Q8TBC5, Q9BRK7, Q9H9A0
    Conserved Domains (3) summary
    smart00349
    Location:228 → 265
    KRAB; krueppel associated box
    sd00017
    Location:415 → 435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:46 → 133
    SCAN; SCAN domain

  3. XM_011527238.2 → XP_011525540.1  zinc finger and SCAN domain-containing protein 18 isoform X2

    See identical proteins and their annotated locations for XP_011525540.1

    UniProtKB/Swiss-Prot
    B4DG23, E9PBI0, Q8TBC5, Q9BRK7, Q9H9A0
    Conserved Domains (3) summary
    smart00349
    Location:228 → 265
    KRAB; krueppel associated box
    sd00017
    Location:415 → 435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:46 → 133
    SCAN; SCAN domain

  4. XM_005259174.6 → XP_005259231.1  zinc finger and SCAN domain-containing protein 18 isoform X2

    See identical proteins and their annotated locations for XP_005259231.1

    UniProtKB/Swiss-Prot
    B4DG23, E9PBI0, Q8TBC5, Q9BRK7, Q9H9A0
    Conserved Domains (3) summary
    smart00349
    Location:228 → 265
    KRAB; krueppel associated box
    sd00017
    Location:415 → 435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:46 → 133
    SCAN; SCAN domain

  5. XM_011527237.3 → XP_011525539.1  zinc finger and SCAN domain-containing protein 18 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:284 → 321
    KRAB; krueppel associated box
    sd00017
    Location:470 → 490
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:102 → 189
    SCAN; SCAN domain

  6. XM_017027169.3 → XP_016882658.1  zinc finger and SCAN domain-containing protein 18 isoform X3

    UniProtKB/Swiss-Prot
    Q8TBC5
    Related
    ENSP00000412253.2, ENST00000433686.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61180644..61214896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321830.1 → XP_054177805.1  zinc finger and SCAN domain-containing protein 18 isoform X2

  2. XM_054321828.1 → XP_054177803.1  zinc finger and SCAN domain-containing protein 18 isoform X2

  3. XM_054321829.1 → XP_054177804.1  zinc finger and SCAN domain-containing protein 18 isoform X2

  4. XM_054321831.1 → XP_054177806.1  zinc finger and SCAN domain-containing protein 18 isoform X2

  5. XM_054321827.1 → XP_054177802.1  zinc finger and SCAN domain-containing protein 18 isoform X1

  6. XM_054321832.1 → XP_054177807.1  zinc finger and SCAN domain-containing protein 18 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TBC5.2 GenPept UniProtKB/Swiss-Prot:Q8TBC5

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