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ZNF747 zinc finger protein 747 [ Homo sapiens (human) ]

Gene ID: 65988, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF747provided by HGNC
Official Full Name
zinc finger protein 747provided by HGNC
Primary source
HGNC:HGNC:28350
See related
Ensembl:ENSG00000169955 AllianceGenome:HGNC:28350
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 3.6), kidney (RPKM 3.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
16p11.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30530367..30534858, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30917336..30921826, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30541688..30546179, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha L Neighboring gene ITGAL antisense RNA 1 Neighboring gene microRNA 4518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10709 Neighboring gene zinc finger protein 768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30544613-30545124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7378 Neighboring gene Sharpr-MPRA regulatory region 7881 Neighboring gene ZNF747 divergent transcript Neighboring gene RPL7L1 pseudogene 16 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30552221-30552866 Neighboring gene uncharacterized LOC124903677 Neighboring gene Sharpr-MPRA regulatory region 8694

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
  2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Loftus BJ, et al. Genomics, 1999 Sep 15. PMID 10493829
  3. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. Dart AE, et al. J Cell Biol, 2015 Nov 23. PMID 26598620, Free PMC Article
  4. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Adams MD, et al. Nature, 1995 Sep 28. PMID 7566098
  5. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. Virok DP, et al. J Proteome Res, 2011 Apr 1. PMID 21244100

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 747 (ZNF747) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2474

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 747
Names
KRAB domain-containing protein ZNF747

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305018.2 → NP_001291947.1  zinc finger protein 747 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA316824, BC001361, BE327668, BM461939, CA429734, DC305764
    Consensus CDS
    CCDS92140.1
    UniProtKB/TrEMBL
    A0A8I5KWK6, B7ZAD9
    Related
    ENSP00000509633.1, ENST00000693075.1
    Conserved Domains (5) summary
    smart00349
    Location:37 → 96
    KRAB; krueppel associated box
    COG5048
    Location:236 → 273
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:212 → 232
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:37 → 76
    KRAB; KRAB box
    pfam13465
    Location:252 → 275
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001305019.2 → NP_001291948.1  zinc finger protein 747 isoform 2

    See identical proteins and their annotated locations for NP_001291948.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AA316824, AK316254, BC001361, BE327668, BM461939, CA429734
    Consensus CDS
    CCDS76856.1
    UniProtKB/Swiss-Prot
    A8K827, B7WNU3, B7Z5R0, Q59FB4, Q96NW0, Q9BV97
    UniProtKB/TrEMBL
    B7ZAD9
    Related
    ENSP00000457274.1, ENST00000568028.1
    Conserved Domains (5) summary
    smart00349
    Location:37 → 96
    KRAB; krueppel associated box
    COG5048
    Location:235 → 272
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:211 → 231
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:37 → 76
    KRAB; KRAB box
    pfam13465
    Location:251 → 274
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001305020.2 → NP_001291949.1  zinc finger protein 747 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an alternate segment in the 5' coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. These differences result in a frameshift compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA316824, AB209546, BC001361, BE327668, BM461939, BP359683, CA429734
    Consensus CDS
    CCDS76855.1
    UniProtKB/Swiss-Prot
    Q9BV97
    Related
    ENSP00000378528.3, ENST00000395094.3
    Conserved Domains (2) summary
    smart00349
    Location:37 → 77
    KRAB; krueppel associated box
    pfam01352
    Location:37 → 76
    KRAB; KRAB box

  4. NM_023931.4 → NP_076420.1  zinc finger protein 747 isoform 3

    See identical proteins and their annotated locations for NP_076420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate segment in the 5' coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA316824, BC001361, BE327668, BM461939, CA429734
    Consensus CDS
    CCDS10682.1
    Related
    ENSP00000252799.3, ENST00000252799.3
    Conserved Domains (1) summary
    pfam01352
    Location:37 → 77
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    30530367..30534858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    30917336..30921826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BV97.2 GenPept UniProtKB/Swiss-Prot:Q9BV97

Gene LinkOut

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