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ZFTA zinc finger translocation associated [ Homo sapiens (human) ]

Gene ID: 65998, updated on 22-Apr-2024

Summary

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Official Symbol
ZFTAprovided by HGNC
Official Full Name
zinc finger translocation associatedprovided by HGNC
Primary source
HGNC:HGNC:28449
See related
Ensembl:ENSG00000188070 MIM:615699; AllianceGenome:HGNC:28449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C11orf95
Summary
Predicted to be involved in negative regulation of transcription, DNA-templated. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 10.0), endometrium (RPKM 8.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q13.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63759892..63768775, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63749259..63758142, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63527364..63536247, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:63398741-63399940 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 1 Neighboring gene atlastin GTPase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63438213-63438714 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63438715-63439214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3441 Neighboring gene reticulon 3 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:63529087-63529846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3445 Neighboring gene RNA, 7SL, cytoplasmic 596, pseudogene Neighboring gene Sharpr-MPRA regulatory region 949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3446 Neighboring gene spindlin interactor and repressor of chromatin binding

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. C11orf95-RELA fusion present in a primary intracranial extra-axial ependymoma: Report of a case with literature review. Nambirajan A, et al. Neuropathology, 2016 Oct. PMID 27121356
  2. Biology and management of ependymomas. Wu J, et al. Neuro Oncol, 2016 Jul. PMID 27022130, Free PMC Article
  3. C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma. Parker M, et al. Nature, 2014 Feb 27. PMID 24553141, Free PMC Article
  4. Contributions of cytogenetics and molecular cytogenetics to the diagnosis of adipocytic tumors. Nishio J. J Biomed Biotechnol, 2011. PMID 21274402, Free PMC Article
  5. Ependymoma with C11orf95-MAML2 fusion: presenting with granular cell and ganglion cell features. Tamai S, et al. Brain Tumor Pathol, 2021 Jan. PMID 33221956

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas.
    Title: CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas.
  2. Ependymoma-like tumor with mesenchymal differentiation harboring C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified tumor related to ependymoma.
    Title: Ependymoma-like tumor with mesenchymal differentiation harboring C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified tumor related to ependymoma.
  3. C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation.
    Title: C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation.
  4. Ependymoma with C11orf95-MAML2 fusion: presenting with granular cell and ganglion cell features.
    Title: Ependymoma with C11orf95-MAML2 fusion: presenting with granular cell and ganglion cell features.
  5. C11orf95-RELA fusion transcript is thought to be the driver genetic alteration leading to activation of the NFkB pathway in supratentorial ependymomas.
    Title: C11orf95-RELA fusion present in a primary supratentorial ependymoma and recurrent sarcoma.
  6. C11orf95-RELA fusions represent a unique novel mechanism leading to pathological activation of NF-kappaB signaling in supratentorial ependymomas.
    Title: Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to pathological activation of the NF-κB signaling pathway.
  7. Based on a recurrent translocation t(11;16)(q13;p13), the C11orf95-MKL2 fusion gene has been found in eight further cases of chondroid lipomas.
    Title: Presence of C11orf95-MKL2 fusion is a consistent finding in chondroid lipomas: a study of eight cases.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Clone Names

  • MGC3032

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger translocation-associated protein
Names
uncharacterized protein C11orf95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144936.2 → NP_001138408.1  zinc finger translocation-associated protein

    See identical proteins and their annotated locations for NP_001138408.1

    Status: VALIDATED

    Source sequence(s)
    AP006289
    Consensus CDS
    CCDS44636.1
    UniProtKB/Swiss-Prot
    A6NLS7, C9JLR9, Q3C1V4
    Related
    ENSP00000482180.1, ENST00000433688.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    63759892..63768775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448662.2 → XP_024304430.1  zinc finger translocation-associated protein isoform X3

  2. XM_047427477.1 → XP_047283433.1  zinc finger translocation-associated protein isoform X1

  3. XM_047427478.1 → XP_047283434.1  zinc finger translocation-associated protein isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    63749259..63758142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369723.1 → XP_054225698.1  zinc finger translocation-associated protein isoform X3

  2. XM_054369721.1 → XP_054225696.1  zinc finger translocation-associated protein isoform X1

  3. XM_054369722.1 → XP_054225697.1  zinc finger translocation-associated protein isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_023941.1: Suppressed sequence

    Description
    NM_023941.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C9JLR9.1 GenPept UniProtKB/Swiss-Prot:C9JLR9

Gene LinkOut

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