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Gfra4 GDNF family receptor alpha 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 66023, updated on 2-May-2024

Summary

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Official Symbol
Gfra4provided by RGD
Official Full Name
GDNF family receptor alpha 4provided by RGD
Primary source
RGD:620503
See related
Ensembl:ENSRNOG00000021241 AllianceGenome:RGD:620503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables glial cell-derived neurotrophic factor receptor activity. Predicted to be involved in nervous system development. Predicted to act upstream of or within negative regulation of ossification. Located in extracellular space. Orthologous to human GFRA4 (GDNF family receptor alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 12.3), Brain (RPKM 11.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gfra4 in Genome Data Viewer
Location:
3q36
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138707970..138715279, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (118254937..118262252, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123573394..123582431, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547276 Neighboring gene attractin Neighboring gene uncharacterized LOC134486154 Neighboring gene ADAM metallopeptidase domain 33 Neighboring gene sialic acid binding Ig like lectin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian GFRalpha -4, a divergent member of the GFRalpha family of coreceptors for glial cell line-derived neurotrophic factor family ligands, is a receptor for the neurotrophic factor persephin. Masure S, et al. J Biol Chem, 2000 Dec 15. PMID 10958791
  2. Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor alpha4 impairs thyroid calcitonin production in young mice. Lindfors PH, et al. Endocrinology, 2006 May. PMID 16497798
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glial cell-derived neurotrophic factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glial cell-derived neurotrophic factor receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glial cell-derived neurotrophic factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables glial cell-derived neurotrophic factor receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glial cell-derived neurotrophic factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in glial cell-derived neurotrophic factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of ossification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GDNF family receptor alpha-4
Names
GDNF receptor alpha-4
GDNFR-alpha-4
GFR-alpha-4
glial cell line derived neurotrophic factor family receptor alpha 4
persephin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395069.1 → NP_001381998.1  GDNF family receptor alpha-4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q9EPI2, Q9EPI3
    UniProtKB/TrEMBL
    A6HQB7
    Related
    ENSRNOP00000095734.1, ENSRNOT00000104014.1
    Conserved Domains (1) summary
    pfam02351
    Location:131 → 225
    GDNF; GDNF/GAS1 domain

  2. NM_023967.2 → NP_076457.1  GDNF family receptor alpha-4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_076457.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q9EPI2, Q9EPI3
    Related
    ENSRNOP00000042875.2, ENSRNOT00000047947.3
    Conserved Domains (1) summary
    pfam02351
    Location:131 → 225
    GDNF; GDNF/GAS1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    138707970..138715279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762197.4 → XP_008760419.1  GDNF family receptor alpha-4 isoform X4

    UniProtKB/Swiss-Prot
    Q9EPI2, Q9EPI3
    Conserved Domains (1) summary
    pfam02351
    Location:131 → 225
    GDNF; GDNF/GAS1 domain

  2. XM_006235043.5 → XP_006235105.1  GDNF family receptor alpha-4 isoform X3

    Conserved Domains (1) summary
    pfam02351
    Location:192 → 286
    GDNF; GDNF/GAS1 domain

  3. XM_006235042.5 → XP_006235104.1  GDNF family receptor alpha-4 isoform X2

    Conserved Domains (1) summary
    pfam02351
    Location:192 → 286
    GDNF; GDNF/GAS1 domain

  4. XM_006235041.5 → XP_006235103.1  GDNF family receptor alpha-4 isoform X1

    Conserved Domains (1) summary
    pfam02351
    Location:192 → 286
    GDNF; GDNF/GAS1 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPI2.2 GenPept UniProtKB/Swiss-Prot:Q9EPI2

Gene LinkOut

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