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Ypel3 yippee like 3 [ Mus musculus (house mouse) ]

Gene ID: 66090, updated on 21-Apr-2024

Summary

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Official Symbol
Ypel3provided by MGI
Official Full Name
yippee like 3provided by MGI
Primary source
MGI:MGI:1913340
See related
Ensembl:ENSMUSG00000042675 AllianceGenome:MGI:1913340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Suap; 0610043B10Rik; 1190001G19Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of cellular senescence. Predicted to act upstream of or within apoptotic process. Predicted to be located in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system gland; nervous system; and reproductive system. Orthologous to human YPEL3 (yippee like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 190.6), mammary gland adult (RPKM 124.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 69.25 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126376135..126379682)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126776963..126780510)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 3 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E6602 Neighboring gene T-box 6 Neighboring gene protein phosphatase 4, catalytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E6603

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Small unstable apoptotic protein, an apoptosis-associated protein, suppresses proliferation of myeloid cells. Baker SJ. Cancer Res, 2003 Feb 1. PMID 12566317
  2. Why YPEL3 represents a novel tumor suppressor. Berberich SJ, et al. Front Biosci (Landmark Ed), 2011 Jan 1. PMID 21196260
  3. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Hosono K, et al. Gene, 2004 Sep 29. PMID 15556292
  4. YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10. Hosono K, et al. Genomics, 2010 Aug. PMID 20580816
  5. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. Ishimura A, et al. Cell Tissue Res, 2016 Mar. PMID 26334721

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein yippee-like 3
Names
small ubiquitinated apoptotic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379293.1 → NP_001366222.1  protein yippee-like 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Variants 1-5 all encode the same isoform (a).
    Source sequence(s)
    AC124505
    UniProtKB/Swiss-Prot
    P61237, Q71E85, Q9D0U3
    UniProtKB/TrEMBL
    D3YZG6
    Conserved Domains (1) summary
    cl13152
    Location:21 → 110
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  2. NM_001379294.1 → NP_001366223.1  protein yippee-like 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 1-3 and 5, encodes the longer isoform (a).
    Source sequence(s)
    AC124505
    UniProtKB/Swiss-Prot
    P61237, Q71E85, Q9D0U3
    UniProtKB/TrEMBL
    D3YZG6
    Conserved Domains (1) summary
    cl13152
    Location:21 → 110
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  3. NM_001379295.1 → NP_001366224.1  protein yippee-like 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1-4, encodes the longer isoform (a).
    Source sequence(s)
    AC124505
    UniProtKB/Swiss-Prot
    P61237, Q71E85, Q9D0U3
    UniProtKB/TrEMBL
    D3YZG6
    Related
    ENSMUSP00000101963.2, ENSMUST00000106356.2
    Conserved Domains (1) summary
    cl13152
    Location:21 → 110
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  4. NM_001379296.1 → NP_001366225.1  protein yippee-like 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform b.
    Source sequence(s)
    AC124505
    Conserved Domains (1) summary
    cl13152
    Location:48 → 81
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  5. NM_001379297.1 → NP_001366226.1  protein yippee-like 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform b.
    Source sequence(s)
    AC124505
    Conserved Domains (1) summary
    cl13152
    Location:48 → 81
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  6. NM_025347.3 → NP_079623.1  protein yippee-like 3 isoform a

    See identical proteins and their annotated locations for NP_079623.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3-5, encodes the longer isoform (a).
    Source sequence(s)
    AC124505
    Consensus CDS
    CCDS21842.1
    UniProtKB/Swiss-Prot
    P61237, Q71E85, Q9D0U3
    UniProtKB/TrEMBL
    D3YZG6
    Related
    ENSMUSP00000037332.6, ENSMUST00000038614.12
    Conserved Domains (1) summary
    cl13152
    Location:21 → 110
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  7. NM_026875.3 → NP_081151.2  protein yippee-like 3 isoform a

    See identical proteins and their annotated locations for NP_081151.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 2-5, encodes the longer isoform (a).
    Source sequence(s)
    AC124505
    Consensus CDS
    CCDS21842.1
    UniProtKB/Swiss-Prot
    P61237, Q71E85, Q9D0U3
    UniProtKB/TrEMBL
    D3YZG6
    Related
    ENSMUSP00000128753.2, ENSMUST00000170882.8
    Conserved Domains (1) summary
    cl13152
    Location:21 → 110
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126376135..126379682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61237.1 GenPept UniProtKB/Swiss-Prot:P61237

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