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Mtarc1 mitochondrial amidoxime reducing component 1 [ Mus musculus (house mouse) ]

Gene ID: 66112, updated on 22-Apr-2024

Summary

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Official Symbol
Mtarc1provided by MGI
Official Full Name
mitochondrial amidoxime reducing component 1provided by MGI
Primary source
MGI:MGI:1913362
See related
Ensembl:ENSMUSG00000026621 AllianceGenome:MGI:1913362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Marc1; Mosc1; 1300013F15Rik
Summary
Predicted to enable molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Predicted to contribute to nitrite reductase (NO-forming) activity. Predicted to be involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Located in mitochondrion. Orthologous to human MTARC1 (mitochondrial amidoxime reducing component 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 141.5), liver E18 (RPKM 31.5) and 4 other tissues See more
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Genomic context

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Location:
1 H5; 1 89.07 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (184518964..184543622, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (184786767..184811743, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2595 Neighboring gene STARR-seq mESC enhancer starr_03307 Neighboring gene H2.0-like homeobox Neighboring gene predicted gene, 51725 Neighboring gene mitochondrial amidoxime reducing component 2 Neighboring gene microRNA 1981 Neighboring gene STARR-positive B cell enhancer ABC_E10073 Neighboring gene STARR-seq mESC enhancer starr_03314 Neighboring gene STARR-positive B cell enhancer ABC_E11112 Neighboring gene predicted gene, 34451

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The N-reductive system composed of mitochondrial amidoxime reducing component (mARC), cytochrome b5 (CYB5B) and cytochrome b5 reductase (CYB5R) is regulated by fasting and high fat diet in mice. Jakobs HH, et al. PLoS One, 2014. PMID 25144769, Free PMC Article
  2. Biochemical and spectroscopic characterization of the human mitochondrial amidoxime reducing components hmARC-1 and hmARC-2 suggests the existence of a new molybdenum enzyme family in eukaryotes. Wahl B, et al. J Biol Chem, 2010 Nov 26. PMID 20861021, Free PMC Article
  3. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes.
    Title: mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes.
  2. Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse.
    Title: Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse.
  3. Fatty liver disease protective MTARC1 p.A165T variant reduces the protein stability of MTARC1.
    Title: Fatty liver disease protective MTARC1 p.A165T variant reduces the protein stability of MTARC1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdenum ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molybdenum ion binding ISO
Inferred from Sequence Orthology
more info
  
enables molybdopterin cofactor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molybdopterin cofactor binding ISO
Inferred from Sequence Orthology
more info
  
enables nitrate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nitrate reductase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to nitrite reductase (NO-forming) activity ISO
Inferred from Sequence Orthology
more info
  
enables nitrite reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on other nitrogenous compounds as donors ISO
Inferred from Sequence Orthology
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular detoxification of nitrogen compound ISO
Inferred from Sequence Orthology
more info
  
involved_in nitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nitrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of nitric-oxide synthase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial amidoxime-reducing component 1
Names
MOCO sulphurase C-terminal domain containing 1
MOSC domain-containing protein 1, mitochondrial
moco sulfurase C-terminal domain-containing protein 1
molybdenum cofactor sulfurase C-terminal domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290273.1 → NP_001277202.1  mitochondrial amidoxime-reducing component 1

    See identical proteins and their annotated locations for NP_001277202.1

    Status: VALIDATED

    Source sequence(s)
    AC131992, AC164539, AI480973, AK004989
    Consensus CDS
    CCDS69987.1
    UniProtKB/Swiss-Prot
    Q8R2L6, Q9CW42
    UniProtKB/TrEMBL
    D3YZZ3
    Related
    ENSMUSP00000035804.7, ENSMUST00000048462.13
    Conserved Domains (3) summary
    COG3217
    Location:60 → 338
    YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
    pfam03473
    Location:207 → 336
    MOSC; MOSC domain
    pfam03476
    Location:58 → 179
    MOSC_N; MOSC N-terminal beta barrel domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    184518964..184543622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497192.5 → XP_006497255.1  mitochondrial amidoxime-reducing component 1 isoform X1

    Conserved Domains (2) summary
    pfam03476
    Location:58 → 179
    MOSC_N; MOSC N-terminal beta barrel domain
    pfam03473
    Location:207 → 248
    MOSC; MOSC domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081361.1: Suppressed sequence

    Description
    NM_001081361.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CW42.2 GenPept UniProtKB/Swiss-Prot:Q9CW42

Gene LinkOut

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