S100a14 S100 calcium binding protein A14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: S100a14provided by MGI
Official Full Name: S100 calcium binding protein A14provided by MGI
Primary source: MGI:MGI:1913416
See related: Ensembl:ENSMUSG00000042306 AllianceGenome:MGI:1913416
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: S114; S100a15; 1110013O05Rik
Summary: Predicted to enable calcium ion binding activity; calcium-dependent protein binding activity; and chemokine receptor binding activity. Predicted to be involved in positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; and toll-like receptor 4 signaling pathway. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in extracellular space and perinuclear region of cytoplasm. Is expressed in alimentary system; lower urinary tract; nasal cavity respiratory epithelium; and skin. Orthologous to human S100A14 (S100 calcium binding protein A14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 24.6), colon adult (RPKM 14.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.25 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (90434156..90436144)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (90526849..90528837)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S100A14 promotes progression and gemcitabine resistance in pancreatic cancer.
Title: S100A14 promotes progression and gemcitabine resistance in pancreatic cancer.
S100A14 enhanced scattering, motility and invasiveness of mouse tumor cells.
Title: Identification of S100A14 as a metastasis-promoting molecule in a murine organotropic metastasis model.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4)
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of granulocyte chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of granulocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor 4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-A14

Names: S100 calcium binding protein A15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163525.2 → NP_001156997.1 protein S100-A14 isoform a

See identical proteins and their annotated locations for NP_001156997.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AA726094, AC160552, AK003669, AK019075, EH105802

Consensus CDS

CCDS17535.1

UniProtKB/Swiss-Prot

Q9D1D8, Q9D2Q8

Related

ENSMUSP00000142428.2, ENSMUST00000199538.5

Conserved Domains (1) summary

cd05022
Location:16 → 101

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
NM_001163526.2 → NP_001156998.1 protein S100-A14 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Isoform b is only 55 aa long, so its biological validity is uncertain.

Source sequence(s)

AC160552, AK003669, EH105802, W54064

Consensus CDS

CCDS50971.1

UniProtKB/TrEMBL

E9Q2K8

Related

ENSMUSP00000129862.3, ENSMUST00000164481.7

Conserved Domains (1) summary

cl08302
Location:11 → 52

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_025393.4 → NP_079669.2 protein S100-A14 isoform a

See identical proteins and their annotated locations for NP_079669.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC160552, AK003669, AK019075, EH105802

Consensus CDS

CCDS17535.1

UniProtKB/Swiss-Prot

Q9D1D8, Q9D2Q8

Related

ENSMUSP00000126821.3, ENSMUST00000167598.6

Conserved Domains (1) summary

cd05022
Location:16 → 101

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...