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Pgls 6-phosphogluconolactonase [ Mus musculus (house mouse) ]

Gene ID: 66171, updated on 23-Jun-2021

Summary

Official Symbol
Pglsprovided by MGI
Official Full Name
6-phosphogluconolactonaseprovided by MGI
Primary source
MGI:MGI:1913421
See related
Ensembl:ENSMUSG00000031807
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Plgs; AI447866; 1110030K05Rik
Expression
Ubiquitous expression in adrenal adult (RPKM 208.2), ovary adult (RPKM 111.5) and 25 other tissues See more
Orthologs
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Genomic context

See Pgls in Genome Data Viewer
Location:
8 B3.3; 8
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72044828..72048911)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71592184..71596267)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (74116083..74120166)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene nucleoredoxin-like 1 Neighboring gene solute carrier family 27 (fatty acid transporter), member 1 Neighboring gene niban apoptosis regulator 3 Neighboring gene collagen beta(1-O)galactosyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 6-phosphogluconolactonase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 6-phosphogluconolactonase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables monosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
 
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pentose-phosphate shunt, oxidative branch ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
6-phosphogluconolactonase
Names
6PGL
NP_001281198.1
NP_079672.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294269.1NP_001281198.1  6-phosphogluconolactonase isoform 2

    See identical proteins and their annotated locations for NP_001281198.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC162033, AK003134, AK003985, BE654173
    Consensus CDS
    CCDS80895.1
    UniProtKB/Swiss-Prot
    Q9CQ60
    UniProtKB/TrEMBL
    D3Z4X1
    Related
    ENSMUSP00000116524.2, ENSMUST00000143441.2
    Conserved Domains (1) summary
    cd01400
    Location:15156
    6PGL; 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard ...
  2. NM_025396.3NP_079672.1  6-phosphogluconolactonase isoform 1

    See identical proteins and their annotated locations for NP_079672.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC162033
    Consensus CDS
    CCDS22400.1
    UniProtKB/Swiss-Prot
    Q9CQ60
    Related
    ENSMUSP00000034264.5, ENSMUST00000034264.11
    Conserved Domains (1) summary
    TIGR01198
    Location:11247
    pgl; 6-phosphogluconolactonase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    72044828..72048911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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