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Msmo1 methylsterol monoxygenase 1 [ Mus musculus (house mouse) ]

Gene ID: 66234, updated on 11-Apr-2024

Summary

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Official Symbol
Msmo1provided by MGI
Official Full Name
methylsterol monoxygenase 1provided by MGI
Primary source
MGI:MGI:1913484
See related
Ensembl:ENSMUSG00000031604 AllianceGenome:MGI:1913484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DESP4; ERG25; Sc4mol; 1500001G16Rik
Summary
Predicted to enable C-4 methylsterol oxidase activity. Predicted to be involved in sterol biosynthetic process. Predicted to act upstream of or within cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MSMO1 (methylsterol monooxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 43.9), CNS E18 (RPKM 39.0) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Msmo1 in Genome Data Viewer
Location:
8 B3.1; 8 32.3 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (65171157..65186822, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (64718123..64733578, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21637 Neighboring gene microRNA 710 Neighboring gene STARR-seq mESC enhancer starr_21638 Neighboring gene carboxypeptidase E Neighboring gene STARR-seq mESC enhancer starr_21639 Neighboring gene STARR-positive B cell enhancer ABC_E2262 Neighboring gene kelch-like 2, Mayven Neighboring gene predicted gene, 46040 Neighboring gene predicted gene, 53437

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNA-Seq analysis reveals a negative role of MSMO1 with a synergized NSDHL expression during adipogenesis of 3T3-L1. Xin Y, et al. Biosci Biotechnol Biochem, 2019 Apr. PMID 30582412
  2. Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. Sukhanova A, et al. Cancer Discov, 2013 Jan. PMID 23125191, Free PMC Article
  3. Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte-somatic communication. Lowther KM, et al. Biol Reprod, 2017 Feb 1. PMID 28203794
  4. Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis. Patra D, et al. PLoS One, 2014. PMID 25147951, Free PMC Article
  5. Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. Pfister S, et al. Int J Dev Biol, 2011. PMID 21305474

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The findings indicate that MSMO1 and NSDHL are novel modulators of adipogenesis.
    Title: RNA-Seq analysis reveals a negative role of MSMO1 with a synergized NSDHL expression during adipogenesis of 3T3-L1.
  2. This work identifies a critical role for SC4MOL and NSDHL in the regulation of EGFR signaling and endocytic trafficking and suggests novel strategies to increase the potency of EGFR antagonists in tumors
    Title: Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-4 methylsterol oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
methylsterol monooxygenase 1
Names
C-4 methylsterol oxidase
sterol-C4-methyl oxidase
sterol-C4-methyl oxidase-like
NP_079712.1
XP_036010125.1
XP_036010126.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025436.3 → NP_079712.1  methylsterol monooxygenase 1

    See identical proteins and their annotated locations for NP_079712.1

    Status: VALIDATED

    Source sequence(s)
    AC152168, AK005090
    Consensus CDS
    CCDS22328.1
    UniProtKB/Swiss-Prot
    Q543V8, Q9CRA4
    Related
    ENSMUSP00000034015.5, ENSMUST00000034015.11
    Conserved Domains (1) summary
    pfam04116
    Location:143 → 274
    FA_hydroxylase; Fatty acid hydroxylase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    65171157..65186822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154232.1 → XP_036010125.1  methylsterol monooxygenase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q543V8, Q9CRA4
    Conserved Domains (1) summary
    pfam04116
    Location:143 → 274
    FA_hydroxylase; Fatty acid hydroxylase superfamily

  2. XM_036154233.1 → XP_036010126.1  methylsterol monooxygenase 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRA4.1 GenPept UniProtKB/Swiss-Prot:Q9CRA4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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