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Aig1 androgen-induced 1 [ Mus musculus (house mouse) ]

Gene ID: 66253, updated on 24-Apr-2024

Summary

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Official Symbol
Aig1provided by MGI
Official Full Name
androgen-induced 1provided by MGI
Primary source
MGI:MGI:1913503
See related
Ensembl:ENSMUSG00000019806 AllianceGenome:MGI:1913503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGI-103; 1500031O19Rik
Summary
Predicted to enable hydrolase activity. Predicted to be involved in long-chain fatty acid catabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in membrane. Predicted to be active in endomembrane system. Orthologous to human AIG1 (androgen induced 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 19.7), colon adult (RPKM 16.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 A2; 10 5.08 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (13522798..13744980, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (13647054..13869038, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13220839-13220948 Neighboring gene STARR-seq mESC enhancer starr_25815 Neighboring gene fucosidase, alpha-L- 2, plasma Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13272745-13273072 Neighboring gene peroxisomal biogenesis factor 3 Neighboring gene adenosine deaminase, tRNA-specific 2 Neighboring gene RIKEN cDNA A730010A20 gene Neighboring gene STARR-seq mESC enhancer starr_25816 Neighboring gene predicted gene, 53613 Neighboring gene predicted gene, 53614 Neighboring gene predicted gene, 32172 Neighboring gene predicted gene, 32105 Neighboring gene predicted gene, 22995

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Androgen-inducible gene 1 increases the ER Ca(2+) content and cell death susceptibility against oxidative stress. Nickel N, et al. Gene, 2016 Jul 15. PMID 27040980
  2. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice. Erikci Ertunc M, et al. J Biol Chem, 2020 May 1. PMID 32152231, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice.
    Title: AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice.
  2. Immunoblotting of mouse tissues demonstrated highest expression of AIG1 in the liver, lung and heart. AIG1 has a complex genomic organization and expresses several splice variants in a tissue-dependent manner; AIG1 over-expression slightly increased susceptibility to oxidative stress. These results indicate that AIG1 plays a role in the control of the intracellular Ca(2+) concentration and cell death susceptibility.
    Title: Androgen-inducible gene 1 increases the ER Ca(2+) content and cell death susceptibility against oxidative stress.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
androgen-induced gene 1 protein
Names
AIG-1
FAHFA hydrolase AIG1
fatty acid esters of hydroxy fatty acids hydrolase AIG1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347362.2 → NP_001334291.1  androgen-induced gene 1 protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks contains an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC134867, AC160027
    Consensus CDS
    CCDS83682.1
    UniProtKB/Swiss-Prot
    Q8CI90, Q9CW23, Q9D8B1
    UniProtKB/TrEMBL
    Q3TS32
    Related
    ENSMUSP00000125366.2, ENSMUST00000162610.8
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 219
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  2. NM_001429343.1 → NP_001416272.1  androgen-induced gene 1 protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC160027

  3. NM_001429344.1 → NP_001416273.1  androgen-induced gene 1 protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC134867, AC160027

  4. NM_001429345.1 → NP_001416274.1  androgen-induced gene 1 protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC134867, AC160027

  5. NM_001429346.1 → NP_001416275.1  androgen-induced gene 1 protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC134867, AC160027

  6. NM_001429347.1 → NP_001416276.1  androgen-induced gene 1 protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC134867, AC160027

  7. NM_001429348.1 → NP_001416277.1  androgen-induced gene 1 protein isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC160027

  8. NM_001429349.1 → NP_001416278.1  androgen-induced gene 1 protein isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC134867, AC160027

  9. NM_001429350.1 → NP_001416279.1  androgen-induced gene 1 protein isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC134867, AC160027

  10. NM_025446.5 → NP_079722.1  androgen-induced gene 1 protein isoform 1

    See identical proteins and their annotated locations for NP_079722.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC134867, AC160027
    Consensus CDS
    CCDS23703.1
    UniProtKB/Swiss-Prot
    Q9D8B1
    Related
    ENSMUSP00000019942.6, ENSMUST00000019942.6
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 219
    Far-17a_AIG1; FAR-17a/AIG1-like protein

RNA

  1. NR_190726.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC134867, AC160027

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    13522798..13744980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155953.1 → XP_036011846.1  androgen-induced gene 1 protein isoform X3

    UniProtKB/TrEMBL
    H7BX91
    Related
    ENSMUSP00000101174.4, ENSMUST00000105534.10
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 173
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  2. XM_036155956.1 → XP_036011849.1  androgen-induced gene 1 protein isoform X5

    Conserved Domains (1) summary
    pfam04750
    Location:12 → 121
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  3. XM_030245214.2 → XP_030101074.1  androgen-induced gene 1 protein isoform X2

    Conserved Domains (1) summary
    pfam04750
    Location:12 → 167
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  4. XM_036155954.1 → XP_036011847.1  androgen-induced gene 1 protein isoform X4

    Conserved Domains (1) summary
    pfam04750
    Location:1 → 105
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  5. XM_036155955.1 → XP_036011848.1  androgen-induced gene 1 protein isoform X4

    Conserved Domains (1) summary
    pfam04750
    Location:1 → 105
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  6. XM_030245216.2 → XP_030101076.1  androgen-induced gene 1 protein isoform X4

    Conserved Domains (1) summary
    pfam04750
    Location:1 → 105
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  7. XM_006512812.4 → XP_006512875.1  androgen-induced gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam04750
    Location:12 → 167
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  8. XM_030245217.2 → XP_030101077.1  androgen-induced gene 1 protein isoform X6

    Conserved Domains (1) summary
    pfam04750
    Location:12 → 52
    Far-17a_AIG1; FAR-17a/AIG1-like protein

RNA

  1. XR_004936247.1 RNA Sequence

  2. XR_004936246.1 RNA Sequence

  3. XR_003948769.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8B1.2 GenPept UniProtKB/Swiss-Prot:Q9D8B1

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