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Aamdc adipogenesis associated Mth938 domain containing [ Mus musculus (house mouse) ]

Gene ID: 66273, updated on 5-Mar-2024

Summary

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Official Symbol
Aamdcprovided by MGI
Official Full Name
adipogenesis associated Mth938 domain containingprovided by MGI
Primary source
MGI:MGI:1913523
See related
Ensembl:ENSMUSG00000035642 AllianceGenome:MGI:1913523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LI2; 1810020D17Rik; 1810037D19Rik
Summary
Acts upstream of or within negative regulation of apoptotic process; positive regulation of fat cell differentiation; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm. Is expressed in central nervous system; embryo; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human AAMDC (adipogenesis associated Mth938 domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 15.8), kidney adult (RPKM 15.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E1; 7 53.54 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97199538..97228723, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97550329..97579557, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerisation domain containing 14 Neighboring gene STARR-positive B cell enhancer ABC_E4950 Neighboring gene integrator complex subunit 4 Neighboring gene predicted gene, 24412 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta, pseudogene 1 Neighboring gene ribosomal protein L15, pseudogene 5 Neighboring gene remodeling and spacing factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of LOC66273 isoform 2, a novel Mth938 containing protein, in MAPK pathway. Wang H, et al. Front Biosci (Elite Ed), 2011 Jun 1. PMID 21622130
  2. LOC66273 isoform 2, a novel protein highly expressed in white adipose tissue, induces adipogenesis in 3T3-L1 cells. Ma X, et al. J Nutr, 2012 Mar. PMID 22279136
  3. Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation. Kuninger D, et al. Genomics, 2004 Nov. PMID 15475267
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of fat cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mth938 domain-containing protein
Names
UPF0366 protein C11orf67 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177945.1 → NP_001171416.1  mth938 domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001171416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC149605, AW124043, BC062811, BY259812
    Consensus CDS
    CCDS52316.1
    UniProtKB/TrEMBL
    D3YWY5, D3YZD8
    Related
    ENSMUSP00000115672.2, ENSMUST00000154853.8
    Conserved Domains (1) summary
    cd05126
    Location:33 → 148
    Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...

  2. NM_001177946.1 → NP_001171417.1  mth938 domain-containing protein isoform 3

    See identical proteins and their annotated locations for NP_001171417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC149605, BC062811, BY259812
    Consensus CDS
    CCDS52315.1
    UniProtKB/TrEMBL
    D3Z1Q3
    Related
    ENSMUSP00000072508.6, ENSMUST00000072725.12
    Conserved Domains (1) summary
    cl00182
    Location:33 → 116
    Mth938-like; Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a ...

  3. NM_001177947.1 → NP_001171418.1  mth938 domain-containing protein isoform 4

    See identical proteins and their annotated locations for NP_001171418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks two coding exons, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC149605, AK008195, BC062811, BY259812
    Consensus CDS
    CCDS52314.1
    UniProtKB/Swiss-Prot
    Q8R0P4
    Related
    ENSMUSP00000116214.2, ENSMUST00000138060.3
    Conserved Domains (1) summary
    cl00182
    Location:5 → 88
    Mth938-like; Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a ...

  4. NM_183251.3 → NP_899074.2  mth938 domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_899074.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA065573, AC149605, BC062811, BY259812
    Consensus CDS
    CCDS21461.1
    UniProtKB/Swiss-Prot
    Q8BH71, Q8R0P4
    UniProtKB/TrEMBL
    D3Z442
    Related
    ENSMUSP00000121940.2, ENSMUST00000136757.8
    Conserved Domains (1) summary
    cd05126
    Location:5 → 120
    Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    97199538..97228723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508114.5 → XP_006508177.1  mth938 domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_006508177.1

    UniProtKB/Swiss-Prot
    Q8BH71, Q8R0P4
    UniProtKB/TrEMBL
    D3Z442
    Conserved Domains (1) summary
    cd05126
    Location:5 → 120
    Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0P4.1 GenPept UniProtKB/Swiss-Prot:Q8R0P4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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