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Tpd52l2 tumor protein D52-like 2 [ Mus musculus (house mouse) ]

Gene ID: 66314, updated on 3-Apr-2024

Summary

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Official Symbol
Tpd52l2provided by MGI
Official Full Name
tumor protein D52-like 2provided by MGI
Primary source
MGI:MGI:1913564
See related
Ensembl:ENSMUSG00000000827 AllianceGenome:MGI:1913564
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D54; 2810411G23Rik
Summary
Predicted to enable protein homodimerization activity. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Orthologous to human TPD52L2 (TPD52 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 19.2), bladder adult (RPKM 18.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H4; 2 103.63 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181138951..181160103)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181497142..181517962)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 46 Neighboring gene predicted gene, 22708 Neighboring gene STARR-positive B cell enhancer mm9_chr2:181218272-181218572 Neighboring gene STARR-seq mESC enhancer starr_06754 Neighboring gene STARR-positive B cell enhancer ABC_E274 Neighboring gene abhydrolase domain containing 16B Neighboring gene predicted gene, 25184 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 Neighboring gene STARR-positive B cell enhancer ABC_E3426 Neighboring gene uridine-cytidine kinase 1-like 1 Neighboring gene uridine-cytidine kinase 1-like 1, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
  2. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. McLelland GL, et al. Elife, 2018 Apr 20. PMID 29676259, Free PMC Article
  3. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
  4. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683
  5. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor protein D54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291197.2 → NP_001278126.1  tumor protein D54 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AL929094
    UniProtKB/TrEMBL
    Q9CZ22
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 212
    TPD52; Tumour protein D52 family

  2. NM_001291200.2 → NP_001278129.1  tumor protein D54 isoform c

    See identical proteins and their annotated locations for NP_001278129.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AL929094
    Consensus CDS
    CCDS71219.1
    UniProtKB/TrEMBL
    Q3TAI4, Q9CZ22
    Related
    ENSMUSP00000000844.9, ENSMUST00000000844.15
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 197
    TPD52; Tumour protein D52 family

  3. NM_001291201.2 → NP_001278130.1  tumor protein D54 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
    Source sequence(s)
    AL929094
    UniProtKB/TrEMBL
    Q3TUJ9, Q8BKP1
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 163
    TPD52; tumor protein D52 family

  4. NM_001291202.2 → NP_001278131.1  tumor protein D54 isoform e

    See identical proteins and their annotated locations for NP_001278131.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (e) that is shorter than isoform a.
    Source sequence(s)
    AL929094
    Consensus CDS
    CCDS71220.1
    UniProtKB/TrEMBL
    Q8BKP1, Q9CZ22
    Related
    ENSMUSP00000068888.3, ENSMUST00000069712.9
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 191
    TPD52; Tumour protein D52 family

  5. NM_001291203.2 → NP_001278132.1  tumor protein D54 isoform f

    See identical proteins and their annotated locations for NP_001278132.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon in both the central and 3' coding regions, compared to variant 1, resulting in an isoform (f) that is shorter than isoform a.
    Source sequence(s)
    AL929094
    Consensus CDS
    CCDS71221.1
    UniProtKB/TrEMBL
    Q3TUJ9, Q9CZ22
    Related
    ENSMUSP00000104428.2, ENSMUST00000108800.8
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 177
    TPD52; Tumour protein D52 family

  6. NM_001291204.2 → NP_001278133.1  tumor protein D54 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three alternate exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (g) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AL929094
    UniProtKB/TrEMBL
    Q3TAI4, Q3TUJ9

  7. NM_001373959.2 → NP_001360888.1  tumor protein D54 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL929094
    Consensus CDS
    CCDS89610.1
    UniProtKB/TrEMBL
    A2AUD5, Q9CZ22
    Related
    ENSMUSP00000104427.4, ENSMUST00000108799.10
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 220
    TPD52; tumor protein D52 family

  8. NM_001373960.2 → NP_001360889.1  tumor protein D54 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL929094
    UniProtKB/TrEMBL
    Q9CZ22
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 201
    TPD52; tumor protein D52 family

  9. NM_001373961.2 → NP_001360890.1  tumor protein D54 isoform j

    Status: VALIDATED

    Source sequence(s)
    AL929094
    UniProtKB/TrEMBL
    Q9CZ22
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 200
    TPD52; tumor protein D52 family

  10. NM_001406353.1 → NP_001393282.1  tumor protein D54 isoform k

    Status: VALIDATED

    Source sequence(s)
    AL929094

  11. NM_001406354.1 → NP_001393283.1  tumor protein D54 isoform l

    Status: VALIDATED

    Source sequence(s)
    AL929094

  12. NM_001406355.1 → NP_001393284.1  tumor protein D54 isoform m

    Status: VALIDATED

    Source sequence(s)
    AL929094

  13. NM_001406356.1 → NP_001393285.1  tumor protein D54 isoform n

    Status: VALIDATED

    Source sequence(s)
    AL929094
    Related
    ENSMUSP00000138837.2, ENSMUST00000184849.8

  14. NM_001406357.1 → NP_001393286.1  tumor protein D54 isoform o

    Status: VALIDATED

    Source sequence(s)
    AL929094

  15. NM_001406358.1 → NP_001393287.1  tumor protein D54 isoform p

    Status: VALIDATED

    Source sequence(s)
    AL929094

  16. NM_001406359.1 → NP_001393288.1  tumor protein D54 isoform q

    Status: VALIDATED

    Source sequence(s)
    AL929094

  17. NM_001406360.1 → NP_001393289.1  tumor protein D54 isoform r

    Status: VALIDATED

    Source sequence(s)
    AL929094

  18. NM_001406361.1 → NP_001393290.1  tumor protein D54 isoform s

    Status: VALIDATED

    Source sequence(s)
    AL929094

  19. NM_001406362.1 → NP_001393291.1  tumor protein D54 isoform t

    Status: VALIDATED

    Source sequence(s)
    AL929094

  20. NM_001406363.1 → NP_001393292.1  tumor protein D54 isoform u

    Status: VALIDATED

    Source sequence(s)
    AL929094

  21. NM_025482.4 → NP_079758.2  tumor protein D54 isoform b

    See identical proteins and their annotated locations for NP_079758.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AL929094
    Consensus CDS
    CCDS17214.1
    UniProtKB/Swiss-Prot
    Q3TVY1, Q9CYZ2
    UniProtKB/TrEMBL
    Q9CZ22
    Related
    ENSMUSP00000117690.2, ENSMUST00000149163.8
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 211
    TPD52; Tumour protein D52 family

RNA

  1. NR_111899.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an alternate exon in both the 5' and 3' regions, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL929094

  2. NR_176048.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL929094

  3. NR_176049.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL929094

  4. NR_176050.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL929094

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    181138951..181160103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500701.2 → XP_006500764.1  tumor protein D54 isoform X4

    UniProtKB/TrEMBL
    F6VQ81
    Related
    ENSMUST00000183956.8
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 139
    TPD52; tumor protein D52 family

  2. XM_036162449.1 → XP_036018342.1  tumor protein D54 isoform X3

    Conserved Domains (1) summary
    pfam04201
    Location:55 → 138
    TPD52; tumor protein D52 family

  3. XM_036162448.1 → XP_036018341.1  tumor protein D54 isoform X2

    Conserved Domains (1) summary
    pfam04201
    Location:55 → 158
    TPD52; tumor protein D52 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CYZ2.1 GenPept UniProtKB/Swiss-Prot:Q9CYZ2

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