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Senp7 SUMO1/sentrin specific peptidase 7 [ Mus musculus (house mouse) ]

Gene ID: 66315, updated on 13-Apr-2024

Summary

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Official Symbol
Senp7provided by MGI
Official Full Name
SUMO1/sentrin specific peptidase 7provided by MGI
Primary source
MGI:MGI:1913565
See related
Ensembl:ENSMUSG00000052917 AllianceGenome:MGI:1913565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410152H17Rik; 2810413I22Rik; 2900036C23Rik; 6030449K19Rik
Summary
This gene encodes a SUMO deconjugating enzyme of the Sentrin/SUMO-specific protease (SENP) family. The encoded protein is a protease that exhibits deSUMOylating activity towards proteins involved in chromatin remodeling and promotes chromatin relaxation for DNA repair or transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Broad expression in whole brain E14.5 (RPKM 4.4), CNS E18 (RPKM 4.3) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C1.1; 16 33.82 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (55869306..56010394)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (56057526..56190031)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10912 Neighboring gene STARR-positive B cell enhancer ABC_E5549 Neighboring gene PEST proteolytic signal containing nuclear protein Neighboring gene tRNA methyltransferase 10C, mitochondrial RNase P subunit Neighboring gene predicted gene, 22422 Neighboring gene STARR-positive B cell enhancer ABC_E7466 Neighboring gene STARR-positive B cell enhancer ABC_E2467 Neighboring gene STARR-positive B cell enhancer ABC_E7467 Neighboring gene predicted gene, 57818 Neighboring gene STARR-seq mESC enhancer starr_41056 Neighboring gene predicted gene, 41462 Neighboring gene STARR-seq mESC enhancer starr_41058 Neighboring gene mitochondrial ribosomal protein L45 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41059 Neighboring gene STARR-seq mESC enhancer starr_41060 Neighboring gene STARR-seq mESC enhancer starr_41061 Neighboring gene interphotoreceptor matrix proteoglycan 2 Neighboring gene STARR-seq mESC enhancer starr_41062 Neighboring gene STARR-seq mESC enhancer starr_41063 Neighboring gene STARR-seq mESC enhancer starr_41064 Neighboring gene discs, large homolog-associated protein 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Maternal SENP7 programs meiosis architecture and embryo survival in mouse. Huang CJ, et al. Biochim Biophys Acta Mol Cell Res, 2017 Jul. PMID 28315713
  2. Emerging roles of desumoylating enzymes. Kim JH, et al. Biochim Biophys Acta, 2009 Mar. PMID 19162180
  3. The Sumo protease Senp7 is required for proper neuronal differentiation. Juarez-Vicente F, et al. Biochim Biophys Acta, 2016 Jul. PMID 27039038
  4. Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition. Bawa-Khalfe T, et al. Proc Natl Acad Sci U S A, 2012 Oct 23. PMID 23045645, Free PMC Article
  5. The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin. Maison C, et al. Nat Struct Mol Biol, 2012 Mar 4. PMID 22388734

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SENP7 programs zygotic DNA repair and spindle assembly to facilitate maternal-to-zygotic transition. SENP7 intervenes epigenetic scenarios of histone H3 during oocyte and embryo development.
    Title: Maternal SENP7 programs meiosis architecture and embryo survival in mouse.
  2. Senp7 is transiently activated at early stages of neuronal differentiation.
    Title: The Sumo protease Senp7 is required for proper neuronal differentiation.
  3. Depletion of Senp7 delocalizes HP1 alpha from pericentric heterochromatin without affecting H3K9me3 levels.
    Title: The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO-specific endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO-specific endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in antiviral innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein desumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sentrin-specific protease 7
Names
SUMO-1-specific protease 2
SUMO1/sentrin specific protease 7
sentrin/SUMO-specific protease SENP7
NP_001003972.1
NP_001003973.1
NP_001291432.1
NP_001347002.1
NP_079759.2
XP_006522514.1
XP_006522515.1
XP_006522517.1
XP_006522518.1
XP_017172600.1
XP_030105091.1
XP_030105092.1
XP_036015979.1
XP_036015980.1
XP_036015981.1
XP_036015982.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003972.2 → NP_001003972.1  sentrin-specific protease 7 isoform 3

    See identical proteins and their annotated locations for NP_001003972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK012740, AK040314, CN692265
    Consensus CDS
    CCDS28223.1
    UniProtKB/TrEMBL
    Q9CQN9
    Related
    ENSMUSP00000043023.6, ENSMUST00000049128.11

  2. NM_001003973.2 → NP_001003973.1  sentrin-specific protease 7 isoform 4

    See identical proteins and their annotated locations for NP_001003973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK020068, AK040314, CN692265
    Consensus CDS
    CCDS88943.1
    UniProtKB/TrEMBL
    Q9CRF0, Q9CX65
    Related
    ENSMUSP00000156009.2, ENSMUST00000201011.2

  3. NM_001304503.1 → NP_001291432.1  sentrin-specific protease 7 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 5 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154275, AK164354, AV331650
    Consensus CDS
    CCDS84243.1
    UniProtKB/TrEMBL
    A0A0J9YUC9, Q3TPI1
    Related
    ENSMUSP00000144116.2, ENSMUST00000202000.2

  4. NM_001360073.1 → NP_001347002.1  sentrin-specific protease 7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1.
    Source sequence(s)
    AC154275, AC171202
    Conserved Domains (1) summary
    COG5160
    Location:677 → 967
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  5. NM_025483.4 → NP_079759.2  sentrin-specific protease 7 isoform 1

    See identical proteins and their annotated locations for NP_079759.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC154275, AK040314, AK085060
    Consensus CDS
    CCDS28222.1
    UniProtKB/Swiss-Prot
    Q6P398, Q80TA3, Q8BUH8
    Related
    ENSMUSP00000086779.3, ENSMUST00000089362.9
    Conserved Domains (1) summary
    COG5160
    Location:743 → 1033
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    55869306..56010394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160087.1 → XP_036015980.1  sentrin-specific protease 7 isoform X3

    UniProtKB/TrEMBL
    E9Q1L5
    Conserved Domains (1) summary
    COG5160
    Location:716 → 1006
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  2. XM_030249232.2 → XP_030105092.1  sentrin-specific protease 7 isoform X10

    UniProtKB/TrEMBL
    Q9CQN9

  3. XM_036160086.1 → XP_036015979.1  sentrin-specific protease 7 isoform X1

    UniProtKB/Swiss-Prot
    Q6P398, Q80TA3, Q8BUH8
    Conserved Domains (1) summary
    COG5160
    Location:743 → 1033
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  4. XM_006522451.5 → XP_006522514.1  sentrin-specific protease 7 isoform X2

    Conserved Domains (1) summary
    COG5160
    Location:743 → 1010
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  5. XM_006522452.5 → XP_006522515.1  sentrin-specific protease 7 isoform X4

    Conserved Domains (1) summary
    COG5160
    Location:679 → 969
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  6. XM_006522455.5 → XP_006522518.1  sentrin-specific protease 7 isoform X8

    Conserved Domains (1) summary
    COG5160
    Location:613 → 903
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  7. XM_017317111.3 → XP_017172600.1  sentrin-specific protease 7 isoform X3

    UniProtKB/TrEMBL
    E9Q1L5
    Related
    ENSMUSP00000086776.4, ENSMUST00000089360.10
    Conserved Domains (1) summary
    COG5160
    Location:716 → 1006
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  8. XM_036160089.1 → XP_036015982.1  sentrin-specific protease 7 isoform X6

    Conserved Domains (1) summary
    COG5160
    Location:652 → 942
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  9. XM_006522454.5 → XP_006522517.1  sentrin-specific protease 7 isoform X7

    Conserved Domains (1) summary
    COG5160
    Location:650 → 940
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  10. XM_030249231.2 → XP_030105091.1  sentrin-specific protease 7 isoform X9

    Conserved Domains (1) summary
    COG5160
    Location:586 → 876
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  11. XM_036160088.1 → XP_036015981.1  sentrin-specific protease 7 isoform X5

    Conserved Domains (1) summary
    COG5160
    Location:677 → 967
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

RNA

  1. XR_003951814.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003971.1: Suppressed sequence

    Description
    NM_001003971.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BUH8.1 GenPept UniProtKB/Swiss-Prot:Q8BUH8

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