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Knop1 lysine rich nucleolar protein 1 [ Mus musculus (house mouse) ]

Gene ID: 66356, updated on 3-Apr-2024

Summary

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Official Symbol
Knop1provided by MGI
Official Full Name
lysine rich nucleolar protein 1provided by MGI
Primary source
MGI:MGI:1913606
See related
Ensembl:ENSMUSG00000030980 AllianceGenome:MGI:1913606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tsg118; 2310008H09Rik
Summary
Predicted to be located in nucleus. Is expressed in collecting duct and submandibular gland primordium. Orthologous to human KNOP1 (lysine rich nucleolar protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 15.7), testis adult (RPKM 11.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F2; 7 63.66 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (118441440..118454907, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (118842217..118855998, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4970 Neighboring gene centriolar coiled coil protein 110 Neighboring gene STARR-positive B cell enhancer ABC_E4971 Neighboring gene STARR-positive B cell enhancer ABC_E1359 Neighboring gene VPS35 endosomal protein sorting factor like Neighboring gene STARR-positive B cell enhancer mm9_chr7:125909648-125909949 Neighboring gene STARR-seq mESC enhancer starr_20020 Neighboring gene predicted gene, 26147 Neighboring gene STARR-seq mESC enhancer starr_20027 Neighboring gene IQ motif containing K Neighboring gene STARR-seq mESC enhancer starr_20029 Neighboring gene G protein-coupled receptor, family C, group 5, member B Neighboring gene predicted gene, 39076

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation. Valerius MT, et al. Gene Expr Patterns, 2008 May. PMID 18346943, Free PMC Article
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysine-rich nucleolar protein 1
Names
protein C16orf88 homolog
testis-specific gene 118 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168218.2 → NP_001161690.2  lysine-rich nucleolar protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC138717, AC165086
    Consensus CDS
    CCDS52377.1
    Related
    ENSMUSP00000068142.7, ENSMUST00000063607.12

  2. NM_001168219.2 → NP_001161691.2  lysine-rich nucleolar protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an exon in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC138717, AC165086
    Consensus CDS
    CCDS52376.1
    Related
    ENSMUSP00000114727.4, ENSMUST00000126792.9

  3. NM_001168220.2 → NP_001161692.1  lysine-rich nucleolar protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant (4) also lacks an exon in the middle portion of the coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC138717, AC165086
    Consensus CDS
    CCDS52375.1
    UniProtKB/TrEMBL
    K4DI66
    Related
    ENSMUSP00000102159.2, ENSMUST00000106549.9
    Conserved Domains (1) summary
    pfam15477
    Location:222 → 295
    SMAP; Small acidic protein family

  4. NM_001415717.1 → NP_001402646.1  lysine-rich nucleolar protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC138717, AC165086

  5. NM_023197.4 → NP_075686.3  lysine-rich nucleolar protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC138717, AC165086
    Consensus CDS
    CCDS40104.1
    UniProtKB/TrEMBL
    H7BX94
    Related
    ENSMUSP00000102160.6, ENSMUST00000106550.12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    118441440..118454907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2Q2.2 GenPept UniProtKB/Swiss-Prot:Q9Z2Q2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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