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Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 [ Mus musculus (house mouse) ]

Gene ID: 66416, updated on 28-Jun-2021

Summary

Official Symbol
Ndufa7provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit A7provided by MGI
Primary source
MGI:MGI:1913666
See related
Ensembl:ENSMUSG00000041881
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
14.5kD; 14.5kDa; CI-B14.5a; 2400007M02Rik
Summary
This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. Complex I has been biochemically separated into four fractions. The bovine ortholog of this protein has been reported to be part of the I-lambda fraction, which forms the extrinsic globular domain. In humans, deficiencies in complex I are associated with myopathies, encephalomyopathies, and neurodegenerative disorders. Pseudogenes of this gene are located on chromosomes 7 and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in kidney adult (RPKM 76.8), testis adult (RPKM 74.7) and 28 other tissues See more
Orthologs
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Genomic context

See Ndufa7 in Genome Data Viewer
Location:
17; 17 B1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34043546..34057290)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33824572..33838316)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (33961559..33975258)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene KN motif and ankyrin repeat domains 3 Neighboring gene ribosomal protein S28 Neighboring gene CD320 antigen Neighboring gene predicted gene, 52316 Neighboring gene uncharacterized LOC118568329

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in ATP synthesis coupled electron transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial electron transport, NADH to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Names
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a)
NADH-ubiquinone oxidoreductase subunit B14.5a
complex I-B14.5a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023202.4NP_075691.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

    See identical proteins and their annotated locations for NP_075691.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    BC055698, BX522503, CT030732
    Consensus CDS
    CCDS28631.1
    UniProtKB/Swiss-Prot
    Q9Z1P6
    Related
    ENSMUSP00000039692.7, ENSMUST00000048249.8
    Conserved Domains (1) summary
    pfam07347
    Location:5102
    CI-B14_5a; NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)

RNA

  1. NR_103514.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and uses an alternate 3' exon structure compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    CT030732
  2. NR_103515.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' exon structure compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    BY605952, CT030732
    Related
    ENSMUST00000173182.2
  3. NR_103516.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BX518947, BX522503, CT030732
    Related
    ENSMUST00000173132.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34043546..34057290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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