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Mgst3 microsomal glutathione S-transferase 3 [ Mus musculus (house mouse) ]

Gene ID: 66447, updated on 5-Jan-2022

Summary

Official Symbol
Mgst3provided by MGI
Official Full Name
microsomal glutathione S-transferase 3provided by MGI
Primary source
MGI:MGI:1913697
See related
Ensembl:ENSMUSG00000026688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GST-III; AA516734; 2010012L10Rik; 2010306B17Rik; 2700004G04Rik
Summary
Predicted to enable several functions, including glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Predicted to be involved in leukotriene biosynthetic process and lipid metabolic process. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Is expressed in several structures, including alimentary system; integumental system; liver; nervous system; and sensory organ. Orthologous to human MGST3 (microsomal glutathione S-transferase 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in stomach adult (RPKM 1980.6), duodenum adult (RPKM 1260.0) and 18 other tissues See more
Orthologs
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Genomic context

See Mgst3 in Genome Data Viewer
Location:
1; 1 H2.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (167199535..167221410, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (167371966..167393841, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (169302515..169323928, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24182 Neighboring gene aldehyde dehydrogenase 9, subfamily A1 Neighboring gene predicted gene, 34207 Neighboring gene leucine rich repeat containing 52 Neighboring gene retinoid X receptor gamma

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables leukotriene-C4 synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in leukotriene biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
microsomal glutathione S-transferase 3
Names
glutathione peroxidase MGST3
microsomal GST-3
microsomal GST-III
microsomal glutathione S-transferase III
NP_079845.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025569.2NP_079845.1  microsomal glutathione S-transferase 3

    See identical proteins and their annotated locations for NP_079845.1

    Status: VALIDATED

    Source sequence(s)
    AC113970, AK003246
    Consensus CDS
    CCDS15457.1
    UniProtKB/Swiss-Prot
    Q9CPU4
    Related
    ENSMUSP00000028005.3, ENSMUST00000028005.3
    Conserved Domains (1) summary
    pfam01124
    Location:11130
    MAPEG; MAPEG family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    167199535..167221410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_029392.1: Suppressed sequence

    Description
    NM_029392.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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