Cyp2j8 cytochrome P450, family 2, subfamily j, polypeptide 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp2j8provided by MGI
Official Full Name: cytochrome P450, family 2, subfamily j, polypeptide 8provided by MGI
Primary source: MGI:MGI:2449817
See related: Ensembl:ENSMUSG00000082932 AllianceGenome:MGI:2449817
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cyp2j8-ps
Summary: Predicted to enable heme binding activity; isomerase activity; and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway; linoleic acid metabolic process; and xenobiotic metabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 4 C5; 4 44.56 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (96332187..96395634, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (96443950..96507397, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

D4Mit153 (e-PCR), detects polymorphism
- UniSTS:129929

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonic acid 11,12-epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid 14,15-epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables isomerase activity	ISO Inferred from Sequence Orthology more info
enables linoleic acid epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in epoxygenase P450 pathway	ISO Inferred from Sequence Orthology more info
involved_in icosanoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in linoleic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450, family 2, subfamily j, polypeptide 8

Names: cytochrome P450, 2j8; cytochrome P450, family 2, subfamily j, polypeptide 8, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001104927.2 → NP_001098397.1 cytochrome P450, family 2, subfamily j, polypeptide 8 isoform 1

Status: VALIDATED

Source sequence(s)

AL807390

Consensus CDS

CCDS57288.1

UniProtKB/TrEMBL

G3UZ38

Related

ENSMUSP00000134591.2, ENSMUST00000124729.4

Conserved Domains (1) summary

pfam00067
Location:44 → 499

p450; Cytochrome P450
NM_001370972.1 → NP_001357901.1 cytochrome P450, family 2, subfamily j, polypeptide 8 isoform 2

Status: VALIDATED

Source sequence(s)

AL807390

Conserved Domains (1) summary

pfam00067
Location:1 → 355

p450; Cytochrome P450