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Rnf181 ring finger protein 181 [ Mus musculus (house mouse) ]

Gene ID: 66510, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf181provided by MGI
Official Full Name
ring finger protein 181provided by MGI
Primary source
MGI:MGI:1913760
See related
Ensembl:ENSMUSG00000055850 AllianceGenome:MGI:1913760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700047F16Rik; 2500002L14Rik; 6230415N01Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein autoubiquitination. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland; central nervous system; liver lobe; olfactory epithelium; and thymus primordium. Orthologous to human RNF181 (ring finger protein 181). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 73.1), adrenal adult (RPKM 55.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf181 in Genome Data Viewer
Location:
6 C1; 6 32.27 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72336695..72343977, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72359712..72366994, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 39 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:72295216-72295399 Neighboring gene RIKEN cDNA 0610030E20 gene Neighboring gene transmembrane protein 150A Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:72312603-72312712 Neighboring gene vesicle-associated membrane protein 5 Neighboring gene predicted gene, 52494 Neighboring gene vesicle-associated membrane protein 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RN181 regulates the biological behaviors of oral squamous cell carcinoma cells via mediating ERK/MAPK signaling pathway. Li Y, et al. Acta Histochem, 2021 Jul. PMID 34052676
  2. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  4. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
  5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RN181 regulates the biological behaviors of oral squamous cell carcinoma cells via mediating ERK/MAPK signaling pathway.
    Title: RN181 regulates the biological behaviors of oral squamous cell carcinoma cells via mediating ERK/MAPK signaling pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103058

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF181
Names
RING-type E3 ubiquitin transferase RNF181
NP_001318096.1
NP_001318097.1
NP_001318098.1
NP_001318099.1
NP_001318100.1
NP_001318101.1
NP_001318102.1
NP_079883.3
XP_030111400.1
XP_030111401.1
XP_030111402.1
XP_030111403.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331167.1 → NP_001318096.1  E3 ubiquitin-protein ligase RNF181 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA154118, AC116115, AK018849, AK166904, BY086964
    Consensus CDS
    CCDS85064.1
    UniProtKB/Swiss-Prot
    Q9CY62
    Related
    ENSMUSP00000138327.2, ENSMUST00000154098.3
    Conserved Domains (1) summary
    cd16669
    Location:40 → 85
    RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

  2. NM_001331168.1 → NP_001318097.1  E3 ubiquitin-protein ligase RNF181 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AA154118, AK014094, BY772494
    Consensus CDS
    CCDS90058.1
    UniProtKB/Swiss-Prot
    Q9CY62
    Related
    ENSMUSP00000070370.7, ENSMUST00000069595.13

  3. NM_001331169.1 → NP_001318098.1  E3 ubiquitin-protein ligase RNF181 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA154118, AK166904, BY772494, CK387918
    Consensus CDS
    CCDS85064.1
    UniProtKB/Swiss-Prot
    Q9CY62
    Conserved Domains (1) summary
    cd16669
    Location:40 → 85
    RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

  4. NM_001331170.1 → NP_001318099.1  E3 ubiquitin-protein ligase RNF181 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC116115

  5. NM_001331171.1 → NP_001318100.1  E3 ubiquitin-protein ligase RNF181 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC116115
    Consensus CDS
    CCDS90057.1
    UniProtKB/TrEMBL
    D3YUJ1
    Related
    ENSMUSP00000109729.2, ENSMUST00000114095.2

  6. NM_001331172.1 → NP_001318101.1  E3 ubiquitin-protein ligase RNF181 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC116115

  7. NM_001331173.1 → NP_001318102.1  E3 ubiquitin-protein ligase RNF181 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC116115

  8. NM_025607.4 → NP_079883.3  E3 ubiquitin-protein ligase RNF181 isoform 1

    See identical proteins and their annotated locations for NP_079883.3

    Status: VALIDATED

    Source sequence(s)
    AA154118, AK166904, BY772494
    Consensus CDS
    CCDS20240.1
    UniProtKB/Swiss-Prot
    Q8CEU6, Q9CY62, Q9D2T4
    Related
    ENSMUSP00000066128.6, ENSMUST00000069580.12
    Conserved Domains (1) summary
    cd16669
    Location:87 → 132
    RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

RNA

  1. NR_138579.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA154118, AC116115, AK166904, BB851224, BY772494

  2. NR_138580.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA154118, AK166904, BY772494, DV652726

  3. NR_138581.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116115
    Related
    ENSMUST00000125554.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72336695..72343977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255540.1 → XP_030111400.1  E3 ubiquitin-protein ligase RNF181 isoform X1

    UniProtKB/Swiss-Prot
    Q8CEU6, Q9CY62, Q9D2T4
    Conserved Domains (1) summary
    cd16669
    Location:87 → 132
    RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

  2. XM_030255542.1 → XP_030111402.1  E3 ubiquitin-protein ligase RNF181 isoform X2

    Conserved Domains (1) summary
    cd16669
    Location:40 → 85
    RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

  3. XM_030255541.2 → XP_030111401.1  E3 ubiquitin-protein ligase RNF181 isoform X1

    UniProtKB/Swiss-Prot
    Q8CEU6, Q9CY62, Q9D2T4
    Conserved Domains (1) summary
    cd16669
    Location:87 → 132
    RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

  4. XM_030255543.1 → XP_030111403.1  E3 ubiquitin-protein ligase RNF181 isoform X2

    Conserved Domains (1) summary
    cd16669
    Location:40 → 85
    RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CY62.1 GenPept UniProtKB/Swiss-Prot:Q9CY62

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