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Ubxn6 UBX domain protein 6 [ Mus musculus (house mouse) ]

Gene ID: 66530, updated on 5-Mar-2024

Summary

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Official Symbol
Ubxn6provided by MGI
Official Full Name
UBX domain protein 6provided by MGI
Primary source
MGI:MGI:1913780
See related
Ensembl:ENSMUSG00000019578 AllianceGenome:MGI:1913780
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ubxd1; Ubxdc2; 1200008L11Rik; 2210415J11Rik
Summary
Predicted to be involved in ERAD pathway; endosome to lysosome transport via multivesicular body sorting pathway; and macroautophagy. Predicted to be located in bounding membrane of organelle and cytosol. Predicted to be extrinsic component of membrane. Predicted to be part of protein-containing complex. Orthologous to human UBXN6 (UBX domain protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 158.6), adrenal adult (RPKM 23.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 D; 17 29.14 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56374045..56386333, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56067045..56079333, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene MPN domain containing Neighboring gene bolA-like 3 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:56160654-56160880 Neighboring gene SH3-domain GRB2-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E3206 Neighboring gene STARR-positive B cell enhancer ABC_E9960 Neighboring gene chromatin assembly factor 1, subunit A Neighboring gene STARR-positive B cell enhancer ABC_E100 Neighboring gene HDGF like 2 Neighboring gene nuclear encoded tRNA glutamic acid 4 (anticodon CTC) Neighboring gene perilipin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of UBXD1, a novel UBX domain-containing gene on human chromosome 19p13, and its mouse ortholog. Carim-Todd L, et al. Biochim Biophys Acta, 2001 Jan 26. PMID 11342112
  2. VCP cooperates with UBXD1 to degrade mitochondrial outer membrane protein MCL1 in model of Huntington's disease. Guo X, et al. Biochim Biophys Acta Mol Basis Dis, 2017 Feb. PMID 27913212, Free PMC Article
  3. ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB. Won M, et al. Cell Death Differ, 2022 Jun. PMID 34839354, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  5. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport via multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
UBX domain-containing protein 6
Names
UBX domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379361.1 → NP_001366290.1  UBX domain-containing protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT009719
    UniProtKB/Swiss-Prot
    B8JJA5, Q3TTP1, Q3UG19, Q8C4D6, Q91W79, Q99PL6, Q9D7L9
    Related
    ENSMUSP00000019722.6, ENSMUST00000019722.12
    Conserved Domains (2) summary
    cd10460
    Location:158 → 261
    PUB_UBXD1; PNGase/UBA or UBX (PUB) domain of UBXD1
    cd16119
    Location:336 → 409
    UBX_UBXN6; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 6 (UBXN6) and similar proteins

  2. NM_001379362.1 → NP_001366291.1  UBX domain-containing protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT009719
    Conserved Domains (2) summary
    cd10460
    Location:105 → 208
    PUB_UBXD1; PNGase/UBA or UBX (PUB) domain of UBXD1
    cd16119
    Location:283 → 356
    UBX_UBXN6; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 6 (UBXN6) and similar proteins

  3. NM_024432.3 → NP_077752.1  UBX domain-containing protein 6 isoform 1

    See identical proteins and their annotated locations for NP_077752.1

    Status: VALIDATED

    Source sequence(s)
    AI846693, AK161273, CT009719
    Consensus CDS
    CCDS28893.1
    UniProtKB/Swiss-Prot
    B8JJA5, Q3TTP1, Q3UG19, Q8C4D6, Q91W79, Q99PL6, Q9D7L9
    Conserved Domains (2) summary
    cd10460
    Location:158 → 261
    PUB_UBXD1; PNGase/UBA or UBX (PUB) domain of UBXD1
    cd16119
    Location:336 → 409
    UBX_UBXN6; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 6 (UBXN6) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56374045..56386333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PL6.1 GenPept UniProtKB/Swiss-Prot:Q99PL6

Gene LinkOut

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