U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

H2bc23 H2B clustered histone 23 [ Mus musculus (house mouse) ]

Gene ID: 665596, updated on 8-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
H2bc23provided by MGI
Official Full Name
H2B clustered histone 23provided by MGI
Primary source
MGI:MGI:3702051
See related
Ensembl:ENSMUSG00000069307 AllianceGenome:MGI:3702051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm13646; Hist1h2bq
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in thymus adult (RPKM 100.4), colon adult (RPKM 57.3) and 24 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
13 A3.1; 13 7.98 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21990582..21994369, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21806412..21810199, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33864 Neighboring gene H2A clustered histone 22 Neighboring gene H2B clustered histone 22 Neighboring gene STARR-positive B cell enhancer mm9_chr13:21894945-21895245 Neighboring gene H2A clustered histone 23 Neighboring gene H4 clustered histone 17

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of the mouse histone gene cluster on chromosome 13: 45 histone genes in three patches spread over 1Mb. Wang ZF, et al. Genome Res, 1996 Aug. PMID 8858344
  2. The human and mouse replication-dependent histone genes. Marzluff WF, et al. Genomics, 2002 Nov. PMID 12408966
  3. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables STAT family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
H2b histone family, member A
Names
histone cluster 1, H2bq

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097979.2 → NP_001091448.2  H2b histone family, member A isoform 1

    See identical proteins and their annotated locations for NP_001091448.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1)
    Source sequence(s)
    AL589879
    Consensus CDS
    CCDS49213.1
    UniProtKB/TrEMBL
    A0JLV3, Q8CBB6
    Related
    ENSMUSP00000089343.3, ENSMUST00000091749.4
    Conserved Domains (2) summary
    pfam00125
    Location:3 → 102
    Histone; Core histone H2A/H2B/H3/H4
    cl23830
    Location:12 → 125
    H2B; Histone H2B

  2. NM_001313880.1 → NP_001300809.1  H2b histone family, member A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is intronless and contains a palindromic termination sequence instead of a polyA signal, compared to variant 1. It encodes isoform 2 which has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AL589879
    Consensus CDS
    CCDS84010.1
    UniProtKB/Swiss-Prot
    P10853, Q5SZZ3
    UniProtKB/TrEMBL
    A0JLV3
    Related
    ENSMUSP00000106095.2, ENSMUST00000110469.2
    Conserved Domains (1) summary
    smart00427
    Location:28 → 124
    H2B; Histone H2B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    21990582..21994369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous