Format

Send to:

Choose Destination

H2bc24 H2B clustered histone 24 [ Mus musculus (house mouse) ]

Gene ID: 665622, updated on 23-Jun-2021

Summary

Official Symbol
H2bc24provided by MGI
Official Full Name
H2B clustered histone 24provided by MGI
Primary source
MGI:MGI:3710645
See related
Ensembl:ENSMUSG00000069303
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H4bc24; Hist1h; Gm11277; Hist1h2br
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in thymus adult (RPKM 99.7), colon adult (RPKM 57.2) and 24 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See H2bc24 in Genome Data Viewer
Location:
13; 13 A3.1
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (22017913..22021700)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21833743..21837530)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (21925612..21929399)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene H4 clustered histone 18 Neighboring gene H2A clustered histone 24 Neighboring gene nuclear encoded tRNA leucine 2 (anticodon TAA) Neighboring gene nuclear encoded tRNA isoleucine 11 (anticodon AAT)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the H2bc24 gene: The H2bc24 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
  • Orthologs

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 

General protein information

Preferred Names
histone cluster 1 H2br
Names
H2b histone family member

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110555.1NP_001104025.1  histone cluster 1 H2br isoform 1

    See identical proteins and their annotated locations for NP_001104025.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1)
    Source sequence(s)
    AL589879
    Consensus CDS
    CCDS49215.1
    UniProtKB/TrEMBL
    Q8CBB6
    Related
    ENSMUSP00000136792.2, ENSMUST00000180288.2
    Conserved Domains (2) summary
    pfam00125
    Location:3102
    Histone; Core histone H2A/H2B/H3/H4
    cl23830
    Location:12125
    H2B; Histone H2B
  2. NM_001313878.1NP_001300807.1  histone cluster 1 H2br isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is intronless and contains a palindromic termination sequence instead of a polyA signal, compared to variant 1. It encodes isoform 2 which has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AL589879
    Consensus CDS
    CCDS84011.1
    UniProtKB/Swiss-Prot
    P10853
    Related
    ENSMUSP00000106093.2, ENSMUST00000110467.2
    Conserved Domains (1) summary
    smart00427
    Location:28124
    H2B; Histone H2B

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    22017913..22021700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center