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H2bc24 H2B clustered histone 24 [ Mus musculus (house mouse) ]

Gene ID: 665622, updated on 8-Feb-2024

Summary

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Official Symbol
H2bc24provided by MGI
Official Full Name
H2B clustered histone 24provided by MGI
Primary source
MGI:MGI:3710645
See related
Ensembl:ENSMUSG00000069303 AllianceGenome:MGI:3710645
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H4bc24; Gm11277; Hist1h2br
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in thymus adult (RPKM 99.7), colon adult (RPKM 57.2) and 24 other tissues See more
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Genomic context

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Location:
13 A3.1; 13 8.0 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (22017913..22021700)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21833743..21837530)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene H4 clustered histone 18 Neighboring gene H2A clustered histone 24 Neighboring gene STARR-positive B cell enhancer mm9_chr13:21932431-21932732 Neighboring gene nuclear encoded tRNA leucine 2 (anticodon TAA) Neighboring gene STARR-positive B cell enhancer ABC_E1457 Neighboring gene nuclear encoded tRNA isoleucine 11 (anticodon AAT)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The human and mouse replication-dependent histone genes. Marzluff WF, et al. Genomics, 2002 Nov. PMID 12408966
  2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  3. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Villegas F, et al. Cell Stem Cell, 2019 Feb 7. PMID 30595499
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables STAT family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone cluster 1 H2br
Names
H2b histone family member

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110555.1 → NP_001104025.1  histone cluster 1 H2br isoform 1

    See identical proteins and their annotated locations for NP_001104025.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1)
    Source sequence(s)
    AL589879
    Consensus CDS
    CCDS49215.1
    UniProtKB/TrEMBL
    A0JLV3, Q8CBB6
    Related
    ENSMUSP00000136792.2, ENSMUST00000180288.2
    Conserved Domains (2) summary
    pfam00125
    Location:3 → 102
    Histone; Core histone H2A/H2B/H3/H4
    cl23830
    Location:12 → 125
    H2B; Histone H2B

  2. NM_001313878.1 → NP_001300807.1  histone cluster 1 H2br isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is intronless and contains a palindromic termination sequence instead of a polyA signal, compared to variant 1. It encodes isoform 2 which has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AL589879
    Consensus CDS
    CCDS84011.1
    UniProtKB/Swiss-Prot
    P10853, Q5SZZ3
    UniProtKB/TrEMBL
    A0JLV3
    Related
    ENSMUSP00000106093.2, ENSMUST00000110467.2
    Conserved Domains (1) summary
    smart00427
    Location:28 → 124
    H2B; Histone H2B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    22017913..22021700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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