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Lrrc57 leucine rich repeat containing 57 [ Mus musculus (house mouse) ]

Gene ID: 66606, updated on 5-Mar-2024

Summary

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Official Symbol
Lrrc57provided by MGI
Official Full Name
leucine rich repeat containing 57provided by MGI
Primary source
MGI:MGI:1913856
See related
Ensembl:ENSMUSG00000027286 AllianceGenome:MGI:1913856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810002D13Rik
Summary
Predicted to be located in membrane. Orthologous to human LRRC57 (leucine rich repeat containing 57). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 54.9), cortex adult (RPKM 8.9) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E5; 2 60.37 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120434719..120439989, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120604238..120609508, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931402G19 gene Neighboring gene STARR-seq mESC enhancer starr_05508 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120308865-120309066 Neighboring gene calpain 3 Neighboring gene STARR-seq mESC enhancer starr_05509 Neighboring gene zinc finger protein 106 Neighboring gene STARR-seq mESC enhancer starr_05510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120393240-120393349 Neighboring gene STARR-seq mESC enhancer starr_05511 Neighboring gene synaptosomal-associated protein 23 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120435029-120435138 Neighboring gene STARR-seq mESC enhancer starr_05512 Neighboring gene STARR-positive B cell enhancer ABC_E414 Neighboring gene HAUS augmin-like complex, subunit 2 Neighboring gene StAR related lipid transfer domain containing 9 Neighboring gene STARR-seq mESC enhancer starr_05514 Neighboring gene codanin 1 Neighboring gene tau tubulin kinase 2 Neighboring gene STARR-seq mESC enhancer starr_05516 Neighboring gene STARR-positive B cell enhancer ABC_E3396

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159609.1 → NP_001153081.1  leucine-rich repeat-containing protein 57 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK015684, BC034894, BY081522
    UniProtKB/Swiss-Prot
    Q9D1G5, Q9DC95
    Conserved Domains (2) summary
    COG4886
    Location:45 → 194
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:65 → 88
    LRR_RI; leucine-rich repeat [structural motif]

  2. NM_001159610.1 → NP_001153082.1  leucine-rich repeat-containing protein 57 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC034894, BY081522, BY293050
    UniProtKB/Swiss-Prot
    Q9D1G5, Q9DC95
    Conserved Domains (2) summary
    COG4886
    Location:62 → 211
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:82 → 105
    LRR_RI; leucine-rich repeat [structural motif]

  3. NM_001159612.1 → NP_001153084.1  leucine-rich repeat-containing protein 57 isoform c

    See identical proteins and their annotated locations for NP_001153084.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode isoform c.
    Source sequence(s)
    BC034894, CJ169080
    Consensus CDS
    CCDS16623.1
    UniProtKB/Swiss-Prot
    Q9D1G5, Q9DC95
    UniProtKB/TrEMBL
    Q8JZX5
    Related
    ENSMUSP00000099555.4, ENSMUST00000102497.10
    Conserved Domains (2) summary
    PRK15370
    Location:21 → 211
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:40 → 63
    LRR_RI; leucine-rich repeat [structural motif]

  4. NM_025657.3 → NP_079933.2  leucine-rich repeat-containing protein 57 isoform c

    See identical proteins and their annotated locations for NP_079933.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode isoform c.
    Source sequence(s)
    BC034894, BU604191
    Consensus CDS
    CCDS16623.1
    UniProtKB/Swiss-Prot
    Q9D1G5, Q9DC95
    UniProtKB/TrEMBL
    Q8JZX5
    Related
    ENSMUSP00000099554.2, ENSMUST00000102496.8
    Conserved Domains (2) summary
    PRK15370
    Location:21 → 211
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:40 → 63
    LRR_RI; leucine-rich repeat [structural motif]

RNA

  1. NR_027510.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction at the 3' end of a coding exon compared to variant 1. This results in a frameshift and the transcript being a candidate for nonsense-mediated mRNA decay (NMD). Therefore, it is not thought that this transcript encodes a protein.
    Source sequence(s)
    BC034894, BY081522

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    120434719..120439989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500016.4 → XP_006500079.1  leucine-rich repeat-containing protein 57 isoform X1

    See identical proteins and their annotated locations for XP_006500079.1

    UniProtKB/Swiss-Prot
    Q9D1G5, Q9DC95
    UniProtKB/TrEMBL
    Q8JZX5
    Conserved Domains (2) summary
    PRK15370
    Location:21 → 211
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:40 → 63
    LRR_RI; leucine-rich repeat [structural motif]

RNA

  1. XR_004940692.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1G5.1 GenPept UniProtKB/Swiss-Prot:Q9D1G5

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