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Gpatch4 G patch domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 66614, updated on 5-Mar-2024

Summary

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Official Symbol
Gpatch4provided by MGI
Official Full Name
G patch domain containing 4provided by MGI
Primary source
MGI:MGI:1913864
See related
Ensembl:ENSMUSG00000028069 AllianceGenome:MGI:1913864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpatc4; 2610029K21Rik
Summary
Predicted to enable nucleic acid binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Is expressed in central nervous system and olfactory epithelium. Orthologous to human GPATCH4 (G-patch domain containing 4 (gene/pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.2), liver E14 (RPKM 6.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 38.78 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87950413..87963301)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88043106..88055994)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene hyaluronan and proteoglycan link protein 2 Neighboring gene predicted gene, 19439 Neighboring gene STARR-positive B cell enhancer ABC_E10191 Neighboring gene NAD(P)HX epimerase Neighboring gene tetratricopeptide repeat domain 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
  2. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G patch domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110809.2 → NP_001104279.1  G patch domain-containing protein 4

    See identical proteins and their annotated locations for NP_001104279.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK169111, BI658293, CF616874
    Consensus CDS
    CCDS50948.1
    UniProtKB/Swiss-Prot
    Q3TFK5, Q8VCN2, Q9CU32, Q9D3L4
    Related
    ENSMUSP00000029707.8, ENSMUST00000029707.13
    Conserved Domains (1) summary
    pfam01585
    Location:8 → 55
    G-patch; G-patch domain

  2. NM_001286857.1 → NP_001273786.1  G patch domain-containing protein 4

    See identical proteins and their annotated locations for NP_001273786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC080676, BI658293, CF616874
    Consensus CDS
    CCDS50948.1
    UniProtKB/Swiss-Prot
    Q3TFK5, Q8VCN2, Q9CU32, Q9D3L4
    Related
    ENSMUSP00000141786.2, ENSMUST00000193398.2
    Conserved Domains (1) summary
    pfam01585
    Location:8 → 55
    G-patch; G-patch domain

  3. NM_025663.4 → NP_079939.3  G patch domain-containing protein 4

    See identical proteins and their annotated locations for NP_079939.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC137525
    Consensus CDS
    CCDS50948.1
    UniProtKB/Swiss-Prot
    Q3TFK5, Q8VCN2, Q9CU32, Q9D3L4
    Related
    ENSMUSP00000132699.2, ENSMUST00000166021.8
    Conserved Domains (1) summary
    pfam01585
    Location:8 → 55
    G-patch; G-patch domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87950413..87963301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TFK5.1 GenPept UniProtKB/Swiss-Prot:Q3TFK5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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