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Pnisr PNN interacting serine/arginine-rich [ Mus musculus (house mouse) ]

Gene ID: 66625, updated on 5-Mar-2024

Summary

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Official Symbol
Pnisrprovided by MGI
Official Full Name
PNN interacting serine/arginine-richprovided by MGI
Primary source
MGI:MGI:1913875
See related
Ensembl:ENSMUSG00000028248 AllianceGenome:MGI:1913875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pinsr; Sfrs18; Srsf18; 5730406M06Rik
Summary
Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nuclear speck and presynaptic active zone. Is expressed in several structures, including intestine; liver; nervous system; neural retina; and nose. Orthologous to human PNISR (PNN interacting serine and arginine rich protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 36.1), CNS E14 (RPKM 33.4) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A3; 4 9.06 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (21846621..21876475)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (21846657..21876475)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09730 Neighboring gene STARR-positive B cell enhancer ABC_E3481 Neighboring gene cyclin C Neighboring gene STARR-seq mESC enhancer starr_09732 Neighboring gene STARR-seq mESC enhancer starr_09733 Neighboring gene thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 Neighboring gene ubiquitin specific petidase 45 Neighboring gene RIKEN cDNA 4930528A17 gene Neighboring gene STARR-seq mESC enhancer starr_09734 Neighboring gene coenzyme Q3 methyltransferase Neighboring gene STARR-seq mESC enhancer starr_09735 Neighboring gene STARR-seq mESC enhancer starr_09736 Neighboring gene failed axon connections homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate. Cibi DM, et al. Elife, 2019 Jun 26. PMID 31241461, Free PMC Article
  2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  3. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
arginine/serine-rich protein PNISR
Names
SRrp130
serine/arginine-rich splicing factor 18
serine/arginine-rich-splicing regulatory protein 130
splicing factor, arginine/serine-rich 130
splicing factor, arginine/serine-rich 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369189.1 → NP_001356118.1  arginine/serine-rich protein PNISR isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL772187
    Consensus CDS
    CCDS89720.1
    UniProtKB/Swiss-Prot
    A2AJT4, Q9CS92
    UniProtKB/TrEMBL
    B2RUA1
    Related
    ENSMUSP00000095840.3, ENSMUST00000098238.9
    Conserved Domains (2) summary
    TIGR01642
    Location:643 → 750
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam15996
    Location:223 → 380
    PNISR; Arginine/serine-rich protein PNISR

  2. NM_001369190.1 → NP_001356119.1  arginine/serine-rich protein PNISR isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL772187
    Conserved Domains (2) summary
    TIGR01642
    Location:401 → 508
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam15996
    Location:1 → 138
    PNISR; Arginine/serine-rich protein PNISR

  3. NM_001369191.1 → NP_001356120.1  arginine/serine-rich protein PNISR isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL772187
    Conserved Domains (2) summary
    TIGR01642
    Location:401 → 508
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam15996
    Location:1 → 138
    PNISR; Arginine/serine-rich protein PNISR

  4. NM_025669.2 → NP_079945.1  arginine/serine-rich protein PNISR isoform 1

    See identical proteins and their annotated locations for NP_079945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL772187
    Consensus CDS
    CCDS51129.1
    UniProtKB/TrEMBL
    A2AJT5, B2RUA1
    Related
    ENSMUSP00000029911.6, ENSMUST00000029911.12
    Conserved Domains (2) summary
    TIGR01642
    Location:643 → 750
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam15996
    Location:223 → 380
    PNISR; Arginine/serine-rich protein PNISR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    21846621..21876475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320353.3 → XP_017175842.1  arginine/serine-rich protein PNISR isoform X3

  2. XM_030253702.2 → XP_030109562.1  arginine/serine-rich protein PNISR isoform X2

    UniProtKB/TrEMBL
    B2RUA1
    Conserved Domains (2) summary
    TIGR01642
    Location:548 → 655
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam15996
    Location:128 → 285
    PNISR; Arginine/serine-rich protein PNISR

  3. XM_006538184.5 → XP_006538247.1  arginine/serine-rich protein PNISR isoform X1

    See identical proteins and their annotated locations for XP_006538247.1

    UniProtKB/TrEMBL
    A2AJT5, B2RUA1
    Conserved Domains (2) summary
    TIGR01642
    Location:643 → 750
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam15996
    Location:223 → 380
    PNISR; Arginine/serine-rich protein PNISR
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AJT4.1 GenPept UniProtKB/Swiss-Prot:A2AJT4

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