Srp72 signal recognition particle 72 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srp72provided by MGI
Official Full Name: signal recognition particle 72provided by MGI
Primary source: MGI:MGI:1333795
See related: Ensembl:ENSMUSG00000036323 AllianceGenome:MGI:1333795
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 72kDa; 5730576P14Rik
Summary: Predicted to enable 7S RNA binding activity; TPR domain binding activity; and signal recognition particle binding activity. Predicted to contribute to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in endoplasmic reticulum and nucleolus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Orthologous to human SRP72 (signal recognition particle 72). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 28.9), limb E14.5 (RPKM 23.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.3; 5 41.45 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (77122548..77147782)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (76974701..76999935)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126191 (e-PCR)
- UniSTS:162899

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH139020 (e-PCR)
- UniSTS:221106

AI132477 (e-PCR)
- UniSTS:179182

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 7S RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables 7S RNA binding	ISO Inferred from Sequence Orthology more info
enables TPR domain binding	ISO Inferred from Sequence Orthology more info
contributes_to ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to ribosome binding	ISO Inferred from Sequence Orthology more info
enables signal recognition particle binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
part_of signal recognition particle	ISO Inferred from Sequence Orthology more info
part_of signal recognition particle, endoplasmic reticulum targeting	IBA Inferred from Biological aspect of Ancestor more info
part_of signal recognition particle, endoplasmic reticulum targeting	ISA Inferred from Sequence Alignment more info	PubMed
part_of signal recognition particle, endoplasmic reticulum targeting	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal recognition particle subunit SRP72

Names: signal recognition particle 72 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025691.1 → NP_079967.1 signal recognition particle subunit SRP72

See identical proteins and their annotated locations for NP_079967.1

Status: VALIDATED

Source sequence(s)

AK017869, AK133784, BE635216, BY393170, BY647692

Consensus CDS

CCDS39119.1

UniProtKB/TrEMBL

E9Q740, F8VQC1

Related

ENSMUSP00000098648.4, ENSMUST00000101087.10

Conserved Domains (5) summary

sd00006
Location:176 → 204

TPR; TPR repeat [structural motif]

sd00004
Location:341 → 367

PPR; PPR repeat [structural motif]

pfam08492
Location:531 → 584

SRP72; SRP72 RNA-binding domain

pfam17004
Location:36 → 157

SRP_TPR_like; Putative TPR-like repeat

cl26002
Location:24 → 503

TPR_11; TPR repeat