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Ccnh cyclin H [ Mus musculus (house mouse) ]

Gene ID: 66671, updated on 11-Apr-2024

Summary

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Official Symbol
Ccnhprovided by MGI
Official Full Name
cyclin Hprovided by MGI
Primary source
MGI:MGI:1913921
See related
Ensembl:ENSMUSG00000021548 AllianceGenome:MGI:1913921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330408H09Rik
Summary
Enables kinase activity. Predicted to be involved in several processes, including protein stabilization; regulation of cyclin-dependent protein serine/threonine kinase activity; and transcription initiation from RNA polymerase II promoter. Located in nucleus. Is expressed in cerebellum; cranium; and limb mesenchyme. Orthologous to human CCNH (cyclin H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.7), CNS E18 (RPKM 11.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 C3; 13 45.05 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (85337504..85361850)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (85189377..85213731)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35175 Neighboring gene STARR-seq mESC enhancer starr_35176 Neighboring gene smoothened homolog pseudogene Neighboring gene NADH-ubiquinone oxidoreductase chain 5-like Neighboring gene STARR-seq mESC enhancer starr_35177 Neighboring gene STARR-seq mESC enhancer starr_35178 Neighboring gene RAS p21 protein activator 1 Neighboring gene STARR-seq mESC enhancer starr_35180 Neighboring gene STARR-seq mESC enhancer starr_35181 Neighboring gene STARR-positive B cell enhancer mm9_chr13:85569683-85569983 Neighboring gene STARR-seq mESC enhancer starr_35182 Neighboring gene STARR-seq mESC enhancer starr_35183 Neighboring gene STARR-seq mESC enhancer starr_35184 Neighboring gene high mobility group box 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inactivation of the retinoblastoma tumor suppressor induces apoptosis protease-activating factor-1 dependent and independent apoptotic pathways during embryogenesis. Guo Z, et al. Cancer Res, 2001 Dec 1. PMID 11731416
  2. Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos. Patel SA, et al. J Biol Chem, 2010 May 14. PMID 20231280, Free PMC Article
  3. Meiotic expression of the cyclin H/Cdk7 complex in male germ cells of the mouse. Kim JM, et al. Biol Reprod, 2001 May. PMID 11319144
  4. Functional interaction of Puralpha with the Cdk2 moiety of cyclin A/Cdk2. Liu H, et al. Biochem Biophys Res Commun, 2005 Mar 25. PMID 15707957
  5. Mouse development and cell proliferation in the absence of D-cyclins. Kozar K, et al. Cell, 2004 Aug 20. PMID 15315760

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CAK-ERCC2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin-dependent protein kinase activating kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH core complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIH holo complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIK complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIK complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347587.1 → NP_001334516.1  cyclin-H isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK078059, BM899601, BQ032543, BY767531
    Consensus CDS
    CCDS84047.1
    UniProtKB/TrEMBL
    E9PWD3, Q3UUW5
    Related
    ENSMUSP00000129349.2, ENSMUST00000163600.8

  2. NM_001347588.1 → NP_001334517.1  cyclin-H isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AK078059, BM899601, BY767531
    UniProtKB/Swiss-Prot
    Q61458

  3. NM_023243.6 → NP_075732.1  cyclin-H isoform a

    See identical proteins and their annotated locations for NP_075732.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK078059, BM899601, BY767531
    Consensus CDS
    CCDS26666.1
    UniProtKB/Swiss-Prot
    Q61458, Q9CVJ0, Q9JHV7
    UniProtKB/TrEMBL
    Q3UUW5
    Related
    ENSMUSP00000022030.5, ENSMUST00000022030.11
    Conserved Domains (3) summary
    TIGR00569
    Location:2 → 308
    ccl1; cyclin ccl1
    smart00385
    Location:62 → 152
    CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
    pfam16899
    Location:162 → 262
    Cyclin_C_2; Cyclin C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    85337504..85361850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517325.4 → XP_006517388.1  cyclin-H isoform X1

    Conserved Domains (1) summary
    TIGR00569
    Location:2 → 213
    ccl1; cyclin ccl1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61458.2 GenPept UniProtKB/Swiss-Prot:Q61458

Gene LinkOut

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