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Dcbld1 discoidin, CUB and LCCL domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 66686, updated on 23-Apr-2024

Summary

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Official Symbol
Dcbld1provided by MGI
Official Full Name
discoidin, CUB and LCCL domain containing 1provided by MGI
Primary source
MGI:MGI:1913936
See related
Ensembl:ENSMUSG00000019891 AllianceGenome:MGI:1913936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4631413K11Rik
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in blood microparticle. Is expressed in Meckel's cartilage and skeleton. Orthologous to human DCBLD1 (discoidin, CUB and LCCL domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 9.1), large intestine adult (RPKM 8.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B3; 10 26.41 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (52109674..52197474)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (52233578..52321378)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Ros1 proto-oncogene Neighboring gene predicted gene 20630 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26667 Neighboring gene STARR-seq mESC enhancer starr_26670 Neighboring gene STARR-seq mESC enhancer starr_26671 Neighboring gene STARR-seq mESC enhancer starr_26672 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene golgi associated PDZ and coiled-coil motif containing Neighboring gene ribosomal protein S19, pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Yoshida Y, et al. Neuron, 2006 Dec 7. PMID 17145500, Free PMC Article
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
discoidin, CUB and LCCL domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347444.2 → NP_001334373.1  discoidin, CUB and LCCL domain-containing protein 1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AC153525, AC155831
    Consensus CDS
    CCDS83696.1
    UniProtKB/Swiss-Prot
    Q9D4J3
    Related
    ENSMUSP00000151265.2, ENSMUST00000218582.2

  2. NM_001429358.1 → NP_001416287.1  discoidin, CUB and LCCL domain-containing protein 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153525, AC155831

  3. NM_001429359.1 → NP_001416288.1  discoidin, CUB and LCCL domain-containing protein 1 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153525, AC155831

  4. NM_025705.5 → NP_079981.2  discoidin, CUB and LCCL domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_079981.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC153525, AC155831
    Consensus CDS
    CCDS23839.1
    UniProtKB/Swiss-Prot
    Q8R327, Q9D4J3, Q9D696
    Related
    ENSMUSP00000068203.6, ENSMUST00000069004.14
    Conserved Domains (2) summary
    cd00041
    Location:32 → 140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl02694
    Location:147 → 239
    LCCL; LCCL domain

RNA

  1. NR_190727.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153525, AC155831

  2. NR_190728.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153525, AC155831

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    52109674..52197474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243196.2 → XP_011241498.1  discoidin, CUB and LCCL domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd00041
    Location:32 → 140
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl02694
    Location:165 → 229
    LCCL; LCCL domain

  2. XM_030245220.1 → XP_030101080.1  discoidin, CUB and LCCL domain-containing protein 1 isoform X2

  3. XM_030245221.2 → XP_030101081.1  discoidin, CUB and LCCL domain-containing protein 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4J3.2 GenPept UniProtKB/Swiss-Prot:Q9D4J3

Gene LinkOut

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