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Rbm4b RNA binding motif protein 4B [ Mus musculus (house mouse) ]

Gene ID: 66704, updated on 11-Apr-2024

Summary

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Official Symbol
Rbm4bprovided by MGI
Official Full Name
RNA binding motif protein 4Bprovided by MGI
Primary source
MGI:MGI:1913954
See related
Ensembl:ENSMUSG00000033760 AllianceGenome:MGI:1913954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lark2; Neosin; 4921506I22Rik
Summary
Predicted to enable mRNA binding activity. Involved in circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and regulation of translation. Acts upstream of or within positive regulation of gene expression. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nuclear speck. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human RBM4B (RNA binding motif protein 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 17.3), CNS E14 (RPKM 10.5) and 26 other tissues See more
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Genomic context

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Location:
19 A; 19 4.11 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4806480..4816199)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4756452..4765946)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene TOP6B like initiator of meiotic double strand breaks Neighboring gene spectrin beta, non-erythrocytic 2 Neighboring gene predicted gene 21992 Neighboring gene STARR-positive B cell enhancer ABC_E1967 Neighboring gene STARR-seq mESC enhancer starr_45357 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45358 Neighboring gene RNA binding motif protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M. Su CH, et al. Mol Cell Biol, 2017 Feb 1. PMID 27821480, Free PMC Article
  2. RBM4 promotes neuronal differentiation and neurite outgrowth by modulating Numb isoform expression. Tarn WY, et al. Mol Biol Cell, 2016 May 15. PMID 27009199, Free PMC Article
  3. LARK activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1. Kojima S, et al. Proc Natl Acad Sci U S A, 2007 Feb 6. PMID 17264215, Free PMC Article
  4. Phylogenetic and molecular characterization of the splicing factor RBM4. Lu CC, et al. PLoS One, 2013. PMID 23527094, Free PMC Article
  5. RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development. D D, et al. Mol Cell Biol, 2018 Jun 15. PMID 29581187, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC115931

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in circadian rhythm IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in entrainment of circadian clock by photoperiod IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein 4B
Names
RNA-binding motif protein 30
RNA-binding protein 30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025717.3 → NP_079993.2  RNA-binding protein 4B

    See identical proteins and their annotated locations for NP_079993.2

    Status: VALIDATED

    Source sequence(s)
    AW475895, BC019488, BF782018
    Consensus CDS
    CCDS29435.1
    UniProtKB/Swiss-Prot
    Q8VE92
    Related
    ENSMUSP00000038256.7, ENSMUST00000036744.8
    Conserved Domains (4) summary
    PTZ00368
    Location:145 → 181
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    smart00343
    Location:161 → 176
    ZnF_C2HC; zinc finger
    cd12606
    Location:2 → 68
    RRM1_RBM4; RNA recognition motif 1 in vertebrate RNA-binding protein 4 (RBM4)
    cd12607
    Location:78 → 144
    RRM2_RBM4; RNA recognition motif 2 in vertebrate RNA-binding protein 4 (RBM4)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4806480..4816199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531824.5 → XP_006531887.1  RNA-binding protein 4B isoform X1

    See identical proteins and their annotated locations for XP_006531887.1

    UniProtKB/Swiss-Prot
    Q8VE92
    Conserved Domains (4) summary
    PTZ00368
    Location:145 → 181
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    smart00343
    Location:161 → 176
    ZnF_C2HC; zinc finger
    cd12606
    Location:2 → 68
    RRM1_RBM4; RNA recognition motif 1 in vertebrate RNA-binding protein 4 (RBM4)
    cd12607
    Location:78 → 144
    RRM2_RBM4; RNA recognition motif 2 in vertebrate RNA-binding protein 4 (RBM4)

  2. XM_006531825.5 → XP_006531888.1  RNA-binding protein 4B isoform X1

    See identical proteins and their annotated locations for XP_006531888.1

    UniProtKB/Swiss-Prot
    Q8VE92
    Conserved Domains (4) summary
    PTZ00368
    Location:145 → 181
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    smart00343
    Location:161 → 176
    ZnF_C2HC; zinc finger
    cd12606
    Location:2 → 68
    RRM1_RBM4; RNA recognition motif 1 in vertebrate RNA-binding protein 4 (RBM4)
    cd12607
    Location:78 → 144
    RRM2_RBM4; RNA recognition motif 2 in vertebrate RNA-binding protein 4 (RBM4)

  3. XM_006531827.5 → XP_006531890.1  RNA-binding protein 4B isoform X2

    UniProtKB/TrEMBL
    A0A494B9C0, A0A494BAP6
    Related
    ENSMUSP00000157577.2, ENSMUST00000236797.2
    Conserved Domains (1) summary
    cl17169
    Location:2 → 68
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_030251030.2 → XP_030106890.1  RNA-binding protein 4B isoform X1

    UniProtKB/Swiss-Prot
    Q8VE92
    Conserved Domains (4) summary
    PTZ00368
    Location:145 → 181
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    smart00343
    Location:161 → 176
    ZnF_C2HC; zinc finger
    cd12606
    Location:2 → 68
    RRM1_RBM4; RNA recognition motif 1 in vertebrate RNA-binding protein 4 (RBM4)
    cd12607
    Location:78 → 144
    RRM2_RBM4; RNA recognition motif 2 in vertebrate RNA-binding protein 4 (RBM4)

  5. XM_006531826.4 → XP_006531889.1  RNA-binding protein 4B isoform X1

    See identical proteins and their annotated locations for XP_006531889.1

    UniProtKB/Swiss-Prot
    Q8VE92
    Conserved Domains (4) summary
    PTZ00368
    Location:145 → 181
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    smart00343
    Location:161 → 176
    ZnF_C2HC; zinc finger
    cd12606
    Location:2 → 68
    RRM1_RBM4; RNA recognition motif 1 in vertebrate RNA-binding protein 4 (RBM4)
    cd12607
    Location:78 → 144
    RRM2_RBM4; RNA recognition motif 2 in vertebrate RNA-binding protein 4 (RBM4)

RNA

  1. XR_001782610.2 RNA Sequence

  2. XR_003952808.1 RNA Sequence

  3. XR_003952803.1 RNA Sequence

  4. XR_001782611.3 RNA Sequence

  5. XR_003952806.2 RNA Sequence

  6. XR_003952809.2 RNA Sequence

  7. XR_003952805.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE92.1 GenPept UniProtKB/Swiss-Prot:Q8VE92

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