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Bcl2l14 BCL2 like 14 [ Mus musculus (house mouse) ]

Gene ID: 66813, updated on 5-Mar-2024

Summary

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Official Symbol
Bcl2l14provided by MGI
Official Full Name
BCL2 like 14provided by MGI
Primary source
MGI:MGI:1914063
See related
Ensembl:ENSMUSG00000030200 AllianceGenome:MGI:1914063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bclg; Bcl-G; 4930452K23Rik; 4933405K19Rik; 9030625M01Rik
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in apoptotic process and positive regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be located in cytosol. Is expressed in alimentary system; early embryo; and genitourinary system. Orthologous to human BCL2L14 (BCL2 like 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 24.0), duodenum adult (RPKM 4.4) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G1; 6 65.22 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (134373292..134415687)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (134396329..134438724)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ets variant 6 Neighboring gene RIKEN cDNA 1700051K13 gene Neighboring gene STARR-seq mESC enhancer starr_17540 Neighboring gene predicted gene 17089 Neighboring gene RIKEN cDNA 4933406J09 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:134288078-134288378 Neighboring gene STARR-seq mESC enhancer starr_17542 Neighboring gene STARR-positive B cell enhancer ABC_E10413 Neighboring gene STARR-positive B cell enhancer mm9_chr6:134339435-134339735 Neighboring gene STARR-seq mESC enhancer starr_17545 Neighboring gene low density lipoprotein receptor-related protein 6 Neighboring gene STARR-seq mESC enhancer starr_17546 Neighboring gene STARR-positive B cell enhancer mm9_chr6:134565289-134565590 Neighboring gene MANSC domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bcl-2 family member Bcl-G is not a proapoptotic protein. Giam M, et al. Cell Death Dis, 2012 Oct 11. PMID 23059823, Free PMC Article
  2. Detection of Bcl-2 family member Bcl-G in mouse tissues using new monoclonal antibodies. Giam M, et al. Cell Death Dis, 2012 Aug 23. PMID 22914326, Free PMC Article
  3. Ubiquitin-like protein MNSFβ covalently binds to Bcl-G and enhances lipopolysaccharide/interferon γ-induced apoptosis in macrophages. Watanabe J, et al. FEBS J, 2013 Mar. PMID 23298187
  4. Ubiquitin-like protein MNSFβ negatively regulates T cell function and survival. Nakamura M, et al. Immunol Invest, 2015. PMID 25180634
  5. Deficiency of monoclonal non-specific suppressor factor beta (MNSFB) promotes pregnancy loss in mice. Gu Y, et al. Mol Reprod Dev, 2015 Jun. PMID 26031240

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
involved_in regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
apoptosis facilitator Bcl-2-like protein 14
Names
BCL2-like 14 (apoptosis facilitator)
apoptosis regulator BCL-G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355686.1 → NP_001342615.1  apoptosis facilitator Bcl-2-like protein 14

    Status: VALIDATED

    Source sequence(s)
    AC155838, AK018579
    Consensus CDS
    CCDS20636.1
    UniProtKB/Swiss-Prot
    Q3TVA7, Q8R141, Q9CPT0, Q9D3W3
    Related
    ENSMUSP00000107591.2, ENSMUST00000111960.2
    Conserved Domains (1) summary
    cl02575
    Location:293 → 316
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

  2. NM_025778.3 → NP_080054.1  apoptosis facilitator Bcl-2-like protein 14

    See identical proteins and their annotated locations for NP_080054.1

    Status: VALIDATED

    Source sequence(s)
    AC155838
    Consensus CDS
    CCDS20636.1
    UniProtKB/Swiss-Prot
    Q3TVA7, Q8R141, Q9CPT0, Q9D3W3
    Related
    ENSMUSP00000032321.5, ENSMUST00000032321.11
    Conserved Domains (1) summary
    cl02575
    Location:293 → 316
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    134373292..134415687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPT0.1 GenPept UniProtKB/Swiss-Prot:Q9CPT0

Gene LinkOut

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