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Acot13 acyl-CoA thioesterase 13 [ Mus musculus (house mouse) ]

Gene ID: 66834, updated on 17-Jan-2022

Summary

Official Symbol
Acot13provided by MGI
Official Full Name
acyl-CoA thioesterase 13provided by MGI
Primary source
MGI:MGI:1914084
See related
Ensembl:ENSMUSG00000006717
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Them2; 0610006O17Rik
Summary
Predicted to enable acyl-CoA hydrolase activity. Involved in negative regulation of cold-induced thermogenesis. Located in mitochondrial matrix. Is expressed in chondrocranium; hindgut; and midgut. Orthologous to human ACOT13 (acyl-CoA thioesterase 13). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in heart adult (RPKM 114.5), kidney adult (RPKM 88.5) and 27 other tissues See more
Orthologs
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Genomic context

See Acot13 in Genome Data Viewer
Location:
13; 13 A3.1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (25001938..25015472, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (24817955..24831489, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (24909824..24923358, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene geminin Neighboring gene cDNA sequence BC005537 Neighboring gene predicted gene, 22358 Neighboring gene RIKEN cDNA D130043K22 gene Neighboring gene tyrosyl-DNA phosphodiesterase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables myristoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acyl-coenzyme A thioesterase 13
Names
hotdog-fold thioesterase superfamily member 2
palmitoyl-CoA hydrolase
thioesterase superfamily member 2
NP_080066.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025790.2NP_080066.1  acyl-coenzyme A thioesterase 13

    See identical proteins and their annotated locations for NP_080066.1

    Status: PROVISIONAL

    Source sequence(s)
    AK002261
    Consensus CDS
    CCDS26380.1
    UniProtKB/Swiss-Prot
    Q9CQR4
    UniProtKB/TrEMBL
    Q4VA32
    Related
    ENSMUSP00000006900.7, ENSMUST00000006900.7
    Conserved Domains (1) summary
    cd03443
    Location:28138
    PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    25001938..25015472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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