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Fuca2 fucosidase, alpha-L- 2, plasma [ Mus musculus (house mouse) ]

Gene ID: 66848, updated on 18-Apr-2024

Summary

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Official Symbol
Fuca2provided by MGI
Official Full Name
fucosidase, alpha-L- 2, plasmaprovided by MGI
Primary source
MGI:MGI:1914098
See related
Ensembl:ENSMUSG00000019810 AllianceGenome:MGI:1914098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610025O11Rik; 5530401P20Rik
Summary
Predicted to enable alpha-L-fucosidase activity. Predicted to be involved in several processes, including fucose metabolic process; glycoside catabolic process; and regulation of entry of bacterium into host cell. Predicted to be located in extracellular space. Predicted to be active in lysosome. Is expressed in nervous system and respiratory system. Orthologous to human FUCA2 (alpha-L-fucosidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 23.4), heart adult (RPKM 17.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 A2; 10 4.86 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (13376314..13394779)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (13500570..13519035)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25812 Neighboring gene LTV1 ribosome biogenesis factor Neighboring gene phosphatase and actin regulator 2 Neighboring gene predicted gene, 46211 Neighboring gene STARR-seq mESC enhancer starr_25813 Neighboring gene STARR-seq mESC enhancer starr_25814 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13220839-13220948 Neighboring gene STARR-seq mESC enhancer starr_25815 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13272745-13273072 Neighboring gene peroxisomal biogenesis factor 3 Neighboring gene adenosine deaminase, tRNA-specific 2 Neighboring gene RIKEN cDNA A730010A20 gene Neighboring gene STARR-seq mESC enhancer starr_25816 Neighboring gene androgen-induced 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Roles of mouse sperm-associated alpha-L-fucosidases in fertilization. Phopin K, et al. Mol Reprod Dev, 2013 Apr. PMID 23426913
  2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-L-fucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-L-fucosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycoside catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of entry of bacterium into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
plasma alpha-L-fucosidase
Names
alpha-L-fucoside fucohydrolase 2
NP_001317127.1
NP_080075.2
XP_006512890.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330198.1 → NP_001317127.1  plasma alpha-L-fucosidase isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC153979, AK017443, AK030320
    Consensus CDS
    CCDS23701.1
    UniProtKB/Swiss-Prot
    Q8VEM3, Q99KR8, Q9D7Z8, Q9DCL7
    UniProtKB/TrEMBL
    Q505Q3
    Related
    ENSMUSP00000055519.6, ENSMUST00000060212.13
    Conserved Domains (2) summary
    smart00812
    Location:24 → 407
    Alpha_L_fucos; Alpha-L-fucosidase
    pfam16757
    Location:370 → 455
    Fucosidase_C; Alpha-L-fucosidase C-terminal domain

  2. NM_025799.5 → NP_080075.2  plasma alpha-L-fucosidase isoform a precursor

    See identical proteins and their annotated locations for NP_080075.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC153979, AI841078, AK030320, CK343852
    Consensus CDS
    CCDS23701.1
    UniProtKB/Swiss-Prot
    Q8VEM3, Q99KR8, Q9D7Z8, Q9DCL7
    UniProtKB/TrEMBL
    Q505Q3
    Related
    ENSMUSP00000113499.3, ENSMUST00000121465.3
    Conserved Domains (2) summary
    smart00812
    Location:24 → 407
    Alpha_L_fucos; Alpha-L-fucosidase
    pfam16757
    Location:370 → 455
    Fucosidase_C; Alpha-L-fucosidase C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    13376314..13394779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512827.4 → XP_006512890.1  plasma alpha-L-fucosidase isoform X1

    See identical proteins and their annotated locations for XP_006512890.1

    UniProtKB/Swiss-Prot
    Q8VEM3, Q99KR8, Q9D7Z8, Q9DCL7
    UniProtKB/TrEMBL
    Q505Q3
    Conserved Domains (2) summary
    smart00812
    Location:24 → 407
    Alpha_L_fucos; Alpha-L-fucosidase
    pfam16757
    Location:370 → 455
    Fucosidase_C; Alpha-L-fucosidase C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KR8.1 GenPept UniProtKB/Swiss-Prot:Q99KR8

Gene LinkOut

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