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Zfp869 zinc finger protein 869 [ Mus musculus (house mouse) ]

Gene ID: 66869, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp869provided by MGI
Official Full Name
zinc finger protein 869provided by MGI
Primary source
MGI:MGI:1914119
See related
Ensembl:ENSMUSG00000054648 AllianceGenome:MGI:1914119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200003I07Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF670 (zinc finger protein 670) and ZNF844 (zinc finger protein 844). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 7.8), CNS E11.5 (RPKM 7.2) and 28 other tissues See more
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Genomic context

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Location:
8 B3.3; 8 33.88 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70157787..70169718, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69705137..69717068, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 868 Neighboring gene STARR-positive B cell enhancer ABC_E9116 Neighboring gene STARR-positive B cell enhancer ABC_E453 Neighboring gene STARR-seq mESC enhancer starr_21742 Neighboring gene zinc finger protein 964 Neighboring gene STARR-positive B cell enhancer ABC_E9117 Neighboring gene STARR-positive B cell enhancer ABC_E242 Neighboring gene predicted gene, 51532 Neighboring gene STARR-positive B cell enhancer ABC_E6642 Neighboring gene zinc finger protein 963

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT). Min SH, et al. J Biol Chem, 2002 Feb 1. PMID 11709547
  2. Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Aubert J, et al. Nat Biotechnol, 2002 Dec. PMID 12447396
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrotransposon silencing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 869
Names
U 2-7-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039965.1 → NP_001035054.1  zinc finger protein 869

    See identical proteins and their annotated locations for NP_001035054.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AK136878, AW495147, BY295637
    Consensus CDS
    CCDS40360.1
    UniProtKB/TrEMBL
    Q9DC47
    Related
    ENSMUSP00000158786.2, ENSMUST00000238418.2
    Conserved Domains (3) summary
    COG5048
    Location:177 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182 → 202
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 56
    KRAB; KRAB box

  2. NM_001039967.1 → NP_001035056.1  zinc finger protein 869

    See identical proteins and their annotated locations for NP_001035056.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. All five variants encode the same protein.
    Source sequence(s)
    AK004570, AK030679, AW495147, BY295637
    Consensus CDS
    CCDS40360.1
    UniProtKB/TrEMBL
    Q9DC47
    Related
    ENSMUSP00000158615.2, ENSMUST00000238408.2
    Conserved Domains (3) summary
    COG5048
    Location:177 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182 → 202
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 56
    KRAB; KRAB box

  3. NM_001359086.1 → NP_001346015.1  zinc finger protein 869

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC157564, AW495147
    Consensus CDS
    CCDS40360.1
    UniProtKB/TrEMBL
    Q9DC47
    Conserved Domains (3) summary
    COG5048
    Location:177 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182 → 202
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 56
    KRAB; KRAB box

  4. NM_001359087.1 → NP_001346016.1  zinc finger protein 869

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC157564, AW495147
    Consensus CDS
    CCDS40360.1
    UniProtKB/TrEMBL
    Q9DC47
    Related
    ENSMUSP00000158663.2, ENSMUST00000238657.2
    Conserved Domains (3) summary
    COG5048
    Location:177 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182 → 202
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 56
    KRAB; KRAB box

  5. NM_181274.4 → NP_851791.1  zinc finger protein 869

    See identical proteins and their annotated locations for NP_851791.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC157564, AW495147
    Consensus CDS
    CCDS40360.1
    UniProtKB/TrEMBL
    Q9DC47
    Related
    ENSMUSP00000158827.2, ENSMUST00000238292.2
    Conserved Domains (3) summary
    COG5048
    Location:177 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182 → 202
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 56
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70157787..70169718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242320.3 → XP_011240622.1  zinc finger protein 869 isoform X1

    See identical proteins and their annotated locations for XP_011240622.1

    UniProtKB/TrEMBL
    Q9DC47
    Conserved Domains (3) summary
    COG5048
    Location:177 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182 → 202
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 56
    KRAB; KRAB box

  2. XM_030243731.2 → XP_030099591.1  zinc finger protein 869 isoform X1

    UniProtKB/TrEMBL
    Q9DC47
    Conserved Domains (3) summary
    COG5048
    Location:177 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182 → 202
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 56
    KRAB; KRAB box

  3. XM_011242319.3 → XP_011240621.1  zinc finger protein 869 isoform X1

    See identical proteins and their annotated locations for XP_011240621.1

    UniProtKB/TrEMBL
    Q9DC47
    Conserved Domains (3) summary
    COG5048
    Location:177 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182 → 202
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 56
    KRAB; KRAB box

  4. XM_011242318.3 → XP_011240620.1  zinc finger protein 869 isoform X1

    See identical proteins and their annotated locations for XP_011240620.1

    UniProtKB/TrEMBL
    Q9DC47
    Conserved Domains (3) summary
    COG5048
    Location:177 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182 → 202
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 56
    KRAB; KRAB box
Nucleotide Protein Strain
Heading Accession and Version

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