U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mrgpra2a MAS-related GPR, member A2A [ Mus musculus (house mouse) ]

Gene ID: 668727, updated on 8-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
Mrgpra2aprovided by MGI
Official Full Name
MAS-related GPR, member A2Aprovided by MGI
Primary source
MGI:MGI:3821888
See related
Ensembl:ENSMUSG00000093973 AllianceGenome:MGI:3821888
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mrga2; Mrgpra2
Summary
Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; mast cell degranulation; and positive regulation of cytokinesis. Orthologous to several human genes including MRGPRX1 (MAS related GPR family member X1); MRGPRX2 (MAS related GPR family member X2); and MRGPRX3 (MAS related GPR family member X3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 3.4), testis adult (RPKM 1.1) and 4 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7 B3; 7 30.84 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (47076073..47101912, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (47426325..47452164, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene MAS-related GPR, member A1 Neighboring gene predicted gene, 25326 Neighboring gene MAS-related GPR, member A2B Neighboring gene MAS-related GPR, member A9 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Dong X, et al. Immunity, 2022 Sep 13. PMID 35882236, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.
    Title: Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC73535

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
MAS-related GPR, member A2A
Names
Mas-related G-protein coupled receptor member A2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172588.2 → NP_001166059.1  MAS-related GPR, member A2A isoform 2

    See identical proteins and their annotated locations for NP_001166059.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC138678
    Consensus CDS
    CCDS52256.1
    UniProtKB/TrEMBL
    A0A0R4J1Z0, W8W3J7
    Related
    ENSMUSP00000124631.2, ENSMUST00000159004.2
    Conserved Domains (1) summary
    cd15105
    Location:40 → 315
    7tmA_MrgprA; mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001384209.1 → NP_001371138.1  MAS-related GPR, member A2A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC138678
    UniProtKB/TrEMBL
    W8W3J7
    Conserved Domains (1) summary
    cd15105
    Location:41 → 316
    7tmA_MrgprA; mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    47076073..47101912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous