Acadsb acyl-Coenzyme A dehydrogenase, short/branched chain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acadsbprovided by MGI
Official Full Name: acyl-Coenzyme A dehydrogenase, short/branched chainprovided by MGI
Primary source: MGI:MGI:1914135
See related: Ensembl:ENSMUSG00000030861 AllianceGenome:MGI:1914135
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SBCAD; 2-MEBCAD; 1300003O09Rik
Summary: Predicted to enable acyl-CoA dehydrogenase activity; electron transfer activity; and identical protein binding activity. Predicted to be involved in fatty acid metabolic process and isoleucine catabolic process. Predicted to act upstream of or within acyl-CoA metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ACADSB (acyl-CoA dehydrogenase short/branched chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 14.5), subcutaneous fat pad adult (RPKM 14.2) and 27 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7 F3; 7 74.03 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (131012330..131047940)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (131410601..131446211)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p.
Title: LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:546623

Acadsb (e-PCR), detects polymorphism
- UniSTS:546623

BB066609 (e-PCR)
- UniSTS:185739

px-23b6 (e-PCR)
- UniSTS:257430

D1Bda38 (e-PCR)
- UniSTS:239785

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2-methylbutanoyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 2-methylpropanoyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables acyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables electron transfer activity	ISO Inferred from Sequence Orthology more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables short-chain fatty acyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in isoleucine catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

Names: 2-methyl branched chain acyl-CoA dehydrogenase; 2-methylbutyryl-coenzyme A dehydrogenase

NP_080102.1

EC 1.3.8.5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025826.4 → NP_080102.1 short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

See identical proteins and their annotated locations for NP_080102.1

Status: VALIDATED

Source sequence(s)

AK004889, AW987640, BY296718

Consensus CDS

CCDS21916.1

UniProtKB/Swiss-Prot

Q9DBL1

UniProtKB/TrEMBL

Q7TMY2

Related

ENSMUSP00000015829.8, ENSMUST00000015829.15

Conserved Domains (2) summary

cd01158
Location:59 → 430

SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases

COG1960
Location:57 → 428

CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]