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Trmt6 tRNA methyltransferase 6 [ Mus musculus (house mouse) ]

Gene ID: 66926, updated on 11-Apr-2024

Summary

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Official Symbol
Trmt6provided by MGI
Official Full Name
tRNA methyltransferase 6provided by MGI
Primary source
MGI:MGI:1914176
See related
Ensembl:ENSMUSG00000037376 AllianceGenome:MGI:1914176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGI-09; mKIAA1153; 3300001M20Rik
Summary
Predicted to be involved in mRNA methylation. Predicted to act upstream of or within tRNA processing. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Is expressed in midbrain ventricular layer; olfactory epithelium; submandibular gland primordium; telencephalon ventricular layer; and thymus primordium. Orthologous to human TRMT6 (tRNA methyltransferase 6 non-catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.7), CNS E14 (RPKM 6.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Trmt6 in Genome Data Viewer
Location:
2 F2; 2 64.74 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132646127..132658127, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132804207..132816054, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene shieldin complex subunit 1 Neighboring gene predicted gene, 52525 Neighboring gene predicted gene, 22245 Neighboring gene chromogranin B Neighboring gene STARR-positive B cell enhancer ABC_E4502 Neighboring gene minichromosome maintenance 8 homologous recombination repair factor Neighboring gene STARR-positive B cell enhancer ABC_E10152 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:132672271-132672472 Neighboring gene cardiolipin synthase 1 Neighboring gene leucine rich repeat neuronal 4 Neighboring gene predicted gene, 54154

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. tRNA-m(1)A modification promotes T cell expansion via efficient MYC protein synthesis. Liu Y, et al. Nat Immunol, 2022 Oct. PMID 36138184
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA (m1A) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA (m1A) methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
Names
mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6
tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6
tRNA methyltransferase 6 homolog
tRNA(m1A58)-methyltransferase subunit TRM6
tRNA(m1A58)MTase subunit TRM6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356442.1 → NP_001343371.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL929562
    Conserved Domains (1) summary
    pfam04189
    Location:14 → 222
    Gcd10p; Gcd10p family

  2. NM_001356443.1 → NP_001343372.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL929562
    Conserved Domains (1) summary
    pfam04189
    Location:1 → 82
    Gcd10p; Gcd10p family

  3. NM_001356444.1 → NP_001343373.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL929562
    Related
    ENSMUST00000147336.8
    Conserved Domains (1) summary
    pfam04189
    Location:1 → 70
    Gcd10p; Gcd10p family

  4. NM_175113.3 → NP_780322.2  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 1

    See identical proteins and their annotated locations for NP_780322.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK028755
    Consensus CDS
    CCDS50728.1
    UniProtKB/Swiss-Prot
    Q3TJZ8, Q3TME7, Q6ZPW8, Q80Y59, Q8CE96, Q8CEU0
    Related
    ENSMUSP00000044687.7, ENSMUST00000039554.7
    Conserved Domains (1) summary
    pfam04189
    Location:21 → 253
    Gcd10p; Gcd10p family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    132646127..132658127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162501.1 → XP_036018394.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X1

    UniProtKB/Swiss-Prot
    Q3TJZ8, Q3TME7, Q6ZPW8, Q80Y59, Q8CE96, Q8CEU0
    Conserved Domains (1) summary
    pfam04189
    Location:21 → 253
    Gcd10p; Gcd10p family

  2. XM_030251972.1 → XP_030107832.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X2

    Conserved Domains (1) summary
    pfam04189
    Location:1 → 70
    Gcd10p; Gcd10p family

  3. XM_036162502.1 → XP_036018395.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X2

    Conserved Domains (1) summary
    pfam04189
    Location:1 → 70
    Gcd10p; Gcd10p family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CE96.1 GenPept UniProtKB/Swiss-Prot:Q8CE96

Gene LinkOut

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