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Kctd20 potassium channel tetramerisation domain containing 20 [ Mus musculus (house mouse) ]

Gene ID: 66989, updated on 3-Apr-2024

Summary

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Official Symbol
Kctd20provided by MGI
Official Full Name
potassium channel tetramerisation domain containing 20provided by MGI
Primary source
MGI:MGI:1914239
See related
Ensembl:ENSMUSG00000005936 AllianceGenome:MGI:1914239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D17Ertd562e; 2410004N11Rik
Summary
Enables identical protein binding activity. Involved in positive regulation of phosphorylation. Located in cytoplasm. Is expressed in dorsal root ganglion; glossopharyngeal ganglion; medulla oblongata basal plate mantle layer; trigeminal ganglion; and vagus ganglion. Orthologous to human KCTD20 (potassium channel tetramerization domain containing 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 19.4), CNS E14 (RPKM 19.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 15.03 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29171420..29188523)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28952436..28969549)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700030A11 gene Neighboring gene BCL2 interacting protein 5 Neighboring gene STARR-seq mESC enhancer starr_42241 Neighboring gene predicted gene 16191 Neighboring gene peroxisomal, testis specific 1 Neighboring gene STARR-positive B cell enhancer ABC_E9948 Neighboring gene STARR-positive B cell enhancer ABC_E2477 Neighboring gene serine/threonine kinase 38 Neighboring gene predicted gene, 23887 Neighboring gene STARR-seq mESC enhancer starr_42244 Neighboring gene STARR-seq mESC enhancer starr_42246 Neighboring gene predicted gene 16196 Neighboring gene STARR-seq mESC enhancer starr_42249

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KCTD20, a relative of BTBD10, is a positive regulator of Akt. Nawa M, et al. BMC Biochem, 2013 Oct 24. PMID 24156551, Free PMC Article
  2. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  3. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Villegas F, et al. Cell Stem Cell, 2019 Feb 7. PMID 30595499
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
BTB/POZ domain-containing protein KCTD20
Names
potassium channel tetramerization domain containing 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356298.2 → NP_001343227.2  BTB/POZ domain-containing protein KCTD20 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT025867
    Related
    ENSMUSP00000113740.2, ENSMUST00000117672.9
    Conserved Domains (2) summary
    cd18386
    Location:44 → 147
    BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
    cl17171
    Location:209 → 248
    PH-like; Pleckstrin homology-like domain

  2. NM_001356299.2 → NP_001343228.1  BTB/POZ domain-containing protein KCTD20 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT025867
    Consensus CDS
    CCDS89045.1
    UniProtKB/TrEMBL
    Q5RKU8, Q80ZU2
    Related
    ENSMUSP00000112890.2, ENSMUST00000118762.9
    Conserved Domains (2) summary
    cd18386
    Location:44 → 147
    BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
    cl17171
    Location:209 → 248
    PH-like; Pleckstrin homology-like domain

  3. NM_001356300.2 → NP_001343229.1  BTB/POZ domain-containing protein KCTD20 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT025867
    Consensus CDS
    CCDS28588.1
    UniProtKB/Swiss-Prot
    Q3TKH8, Q5U5Z7, Q8CDD8, Q9CSC4, Q9CWT1
    UniProtKB/TrEMBL
    A0A3F2YNM3
    Related
    ENSMUSP00000156936.2, ENSMUST00000233197.2
    Conserved Domains (2) summary
    cd18386
    Location:115 → 218
    BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
    cl17171
    Location:280 → 319
    PH-like; Pleckstrin homology-like domain

  4. NM_025888.7 → NP_080164.2  BTB/POZ domain-containing protein KCTD20 isoform 1

    See identical proteins and their annotated locations for NP_080164.2

    Status: VALIDATED

    Source sequence(s)
    CT025867
    Consensus CDS
    CCDS28588.1
    UniProtKB/Swiss-Prot
    Q3TKH8, Q5U5Z7, Q8CDD8, Q9CSC4, Q9CWT1
    UniProtKB/TrEMBL
    A0A3F2YNM3
    Related
    ENSMUSP00000131435.2, ENSMUST00000168507.2
    Conserved Domains (2) summary
    cd18386
    Location:115 → 218
    BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
    cl17171
    Location:280 → 319
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    29171420..29188523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524811.1 → XP_006524874.1  BTB/POZ domain-containing protein KCTD20 isoform X1

    See identical proteins and their annotated locations for XP_006524874.1

    UniProtKB/Swiss-Prot
    Q3TKH8, Q5U5Z7, Q8CDD8, Q9CSC4, Q9CWT1
    UniProtKB/TrEMBL
    A0A3F2YNM3
    Conserved Domains (2) summary
    cd18386
    Location:115 → 218
    BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
    cl17171
    Location:280 → 319
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CDD8.1 GenPept UniProtKB/Swiss-Prot:Q8CDD8

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