Riox2 ribosomal oxygenase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Riox2provided by MGI
Official Full Name: ribosomal oxygenase 2provided by MGI
Primary source: MGI:MGI:1914264
See related: Ensembl:ENSMUSG00000022724 AllianceGenome:MGI:1914264
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mina; 1810047J07Rik; 2410057H13Rik; 3830408E23Rik
Summary: Enables transcription corepressor activity. Predicted to be involved in cell population proliferation; histone H3-K36 demethylation; and histone H3-K4 demethylation. Predicted to act upstream of or within regulation of cell population proliferation. Located in cytosol and nucleus. Part of transcription regulator complex. Is expressed in renal cortex; submandibular gland primordium; tail dorsal root ganglion; telencephalon ventricular layer; and thymus primordium. Orthologous to human RIOX2 (ribosomal oxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 5.3), placenta adult (RPKM 4.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C1.3; 16 34.83 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (59292116..59312895)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (59471753..59492532)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that mdig may contribute to silica-induced lung fibrosis by altering the balance between Th17 and Treg cells.
Title: Oncoprotein mdig contributes to silica-induced pulmonary fibrosis by altering balance between Th17 and Treg T cells.
results demonstrate the TGFbeta signaling pathway plays a critical role in regulating Mina expression and SNP rs4191790 controls heritable variation in Mina expression level, raising important questions regarding the evolution of an allele that uncouples Mina expression from the TGFbeta signaling pathway.
Title: A SNP uncoupling Mina expression from the TGFβ signaling pathway.
Mina: a Th2 response regulator meets TGFbeta.
Title: Mina: a Th2 response regulator meets TGFβ.
Sp1/3 transcription factors trigger Mina expression through additive activity targeted to a cluster of four Sp1/3 binding sites forming the P1 promoter.
Title: Transcriptional activation of Mina by Sp1/3 factors.
Mina53 plays a role in the allergic response to inhaled allergens, possibly through controlling IL-4 production.
Title: Ablation of Mina53 in mice reduces allergic response in the airways.
Mina specifically bound to and repressed the Il4 promoter. Mina overexpression in transgenic mice impaired Il4 expression, whereas its knockdown in primary CD4(+) T cells led to Il4 derepression.
Title: Mina, an Il4 repressor, controls T helper type 2 bias.
Mina53 is prominently expressed in proliferating, undifferentiated spermatogonia, and plays a role in cell proliferation from the spermatogonial stage to the meiotic prophase in spermatogenesis, but not in meiotic divisions per se.
Title: Expression of Mina53, a product of a Myc target gene in mouse testis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI449204 (e-PCR)
- UniSTS:160581

NoName (e-PCR)
- UniSTS:237525

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K4 demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-histidine dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: ribosomal oxygenase 2

Names: MYC-induced nuclear antigen; bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; histone lysine demethylase MINA; myc induced nuclear antigen

NP_080186.3

EC 1.14.11.79

XP_006522542.1

EC 1.14.11.79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.