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Use1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 67023, updated on 5-Mar-2024

Summary

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Official Symbol
Use1provided by MGI
Official Full Name
unconventional SNARE in the ER 1 homolog (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1914273
See related
Ensembl:ENSMUSG00000002395 AllianceGenome:MGI:1914273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D12; Ed2; p31; Q-snare; 2010315L10Rik; 5730403H22Rik
Summary
Predicted to enable SNAP receptor activity. Acts upstream of or within endoplasmic reticulum tubular network organization and regulation of ER to Golgi vesicle-mediated transport. Predicted to be located in COPI-coated vesicle; Golgi apparatus; and plasma membrane. Predicted to be part of SNARE complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including early conceptus; embryo ectoderm; embryo mesoderm; optic vesicle; and primitive streak. Orthologous to human USE1 (unconventional SNARE in the ER 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 55.7), testis adult (RPKM 48.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 34.43 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71819329..71822376)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71366848..71369732)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene adenine phosphoribosyl transferase, pseudogene Neighboring gene 4HAUS augmin-like complex, subunit 8 Neighboring gene STARR-positive B cell enhancer ABC_E1105 Neighboring gene myosin IXb Neighboring gene STARR-positive B cell enhancer ABC_E6650 Neighboring gene occludin/ELL domain containing 1 Neighboring gene nuclear receptor subfamily 2, group F, member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. mED2--a novel gene involved in mouse embryonic development. Duan JZ, et al. Yi Chuan Xue Bao, 2006 Aug. PMID 16939003
  2. Sec22b is a negative regulator of phagocytosis in macrophages. Hatsuzawa K, et al. Mol Biol Cell, 2009 Oct. PMID 19710423, Free PMC Article
  3. Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment. Nieradka A, et al. PLoS One, 2014. PMID 25184340, Free PMC Article
  4. p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival. Uemura T, et al. Mol Cell Biol, 2009 Apr. PMID 19188447, Free PMC Article
  5. Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. Lee PC, et al. Mol Cell, 2013 Apr 25. PMID 23499007, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Grsf1 controls translation of the protein Use1, possibly by positioning the 40S ribosomal subunit and associated translation factors in front of the translation start site.
    Title: Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment.
  2. Uba6 and Use1 promote proteasomal turnover of Ube3a in mouse embryo fibroblasts (MEFs) and catalyze Ube3a ubiquitylation in vitro.
    Title: Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system.
  3. Domain analyses of Sec22b revealed that the R-SNARE motif, a selective domain for forming a SNARE complex with syntaxin18 and/or D12, was responsible for the inhibition of phagocytosis.
    Title: Sec22b is a negative regulator of phagocytosis in macrophages.
  4. p31 is an essential molecule involved in the maintenance of endoplasmic reticulum (ER) morphology and that its deficiency leads to ER stress-induced apoptosis.
    Title: p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endoplasmic reticulum tubular network organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of ER to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in COPI-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vesicle transport protein USE1
Names
USE1-like protein
embryonic development factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145780.1 → NP_001139252.1  vesicle transport protein USE1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate translational start codon, compared to variant 1. The encoded isoform (3) is longer at the N-terminus, compared to isoform 1.
    Source sequence(s)
    BC075695, BY097923
    Consensus CDS
    CCDS52582.1
    UniProtKB/TrEMBL
    E9Q496, Q5I940
    Related
    ENSMUSP00000105680.3, ENSMUST00000110053.9
    Conserved Domains (1) summary
    pfam09753
    Location:31 → 280
    Use1; Membrane fusion protein Use1

  2. NM_025917.4 → NP_080193.1  vesicle transport protein USE1 isoform 1

    See identical proteins and their annotated locations for NP_080193.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AK160726, BC075695, BY286283
    Consensus CDS
    CCDS22390.1
    UniProtKB/Swiss-Prot
    Q3TUK0, Q80V73, Q99MB6, Q9CQ56
    UniProtKB/TrEMBL
    Q5I940
    Related
    ENSMUSP00000019169.8, ENSMUST00000019169.8
    Conserved Domains (1) summary
    pfam09753
    Location:17 → 266
    Use1; Membrane fusion protein Use1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71819329..71822376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154245.1 → XP_036010138.1  vesicle transport protein USE1 isoform X1

    UniProtKB/TrEMBL
    Q5I940
    Conserved Domains (1) summary
    pfam09753
    Location:73 → 324
    Use1; Membrane fusion protein Use1

  2. XM_036154246.1 → XP_036010139.1  vesicle transport protein USE1 isoform X2

    UniProtKB/TrEMBL
    Q5I940
    Conserved Domains (1) summary
    pfam09753
    Location:73 → 323
    Use1; Membrane fusion protein Use1

  3. XM_036154247.1 → XP_036010140.1  vesicle transport protein USE1 isoform X4

    UniProtKB/TrEMBL
    Q5I940
    Conserved Domains (1) summary
    pfam09753
    Location:16 → 267
    Use1; Membrane fusion protein Use1

  4. XM_006509726.2 → XP_006509789.1  vesicle transport protein USE1 isoform X3

    UniProtKB/TrEMBL
    Q5I940
    Conserved Domains (1) summary
    pfam09753
    Location:31 → 281
    Use1; Membrane fusion protein Use1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_029768.3: Suppressed sequence

    Description
    NM_029768.3: This RefSeq was permanently suppressed because the CDS was partial and the transcript retained intronic sequence.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ56.1 GenPept UniProtKB/Swiss-Prot:Q9CQ56

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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