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Ddx17 DEAD box helicase 17 [ Mus musculus (house mouse) ]

Gene ID: 67040, updated on 11-Apr-2024

Summary

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Official Symbol
Ddx17provided by MGI
Official Full Name
DEAD box helicase 17provided by MGI
Primary source
MGI:MGI:1914290
See related
Ensembl:ENSMUSG00000055065 AllianceGenome:MGI:1914290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p72; Gm926; 2610007K22Rik; A430025E01Rik
Summary
This gene encodes the mouse homolog of human DEAD box polypeptide 17. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). RNA helicases of the DEAD-box family are involved in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in limb E14.5 (RPKM 143.7), CNS E14 (RPKM 143.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 37.77 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79411897..79430976, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79527696..79546764, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39186 Neighboring gene predicted gene, 41359 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 4 Neighboring gene STARR-seq mESC enhancer starr_39188 Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 Neighboring gene STARR-seq mESC enhancer starr_39189 Neighboring gene DNA meiotic recombinase 1 Neighboring gene family with sequence similarity 227, member A Neighboring gene STARR-seq mESC enhancer starr_39191 Neighboring gene STARR-seq mESC enhancer starr_39193

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132. Remenyi J, et al. Sci Rep, 2016 Mar 7. PMID 26947125, Free PMC Article
  2. Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis. Wilson BJ, et al. BMC Genomics, 2007 Nov 15. PMID 18005418, Free PMC Article
  3. MTDH-stabilized DDX17 promotes tumor initiation and progression through interacting with YB1 to induce EGFR transcription in Hepatocellular Carcinoma. Jin C, et al. Oncogene, 2023 Jan. PMID 36385375
  4. DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs. Wang SB, et al. Sci Immunol, 2021 Dec 3. PMID 34860583, Free PMC Article
  5. Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation. Hitachi K, et al. EMBO Rep, 2019 Mar. PMID 30622218, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.
    Title: DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.
  2. Mechanistic studies reveal that MeXis interacts with and guides promoter binding of the transcriptional coactivator DDX17. The identification of MeXis as a lncRNA modulator of LXR-dependent gene expression expands understanding of the mechanisms underlying cell type-selective actions of nuclear receptors in physiology and disease.
    Title: Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.
  3. Data show that p72/DDX17 specifically interacts with the miR-132 loop sequence and influences the relative ratio of the mature mice miR-212/132 miRNAs.
    Title: The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132.
  4. Downregulation of DDX5 and DDX17 protein expression during myogenesis and epithelial-to-mesenchymal transdifferentiation contributes to the switching of splicing programs during these processes.
    Title: RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation.
  5. Data indicate that transcriptional coregulator ddx5/ddx17 RNA helicases can simultaneously regulate the transcriptional activity and alternative splicing of NFAT5 transcription factor.
    Title: Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC79147

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lncRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lncRNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in miRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX17
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
DEAD box protein 17
NP_001035277.1
NP_690019.2
NP_951061.1
NP_951062.1
XP_030104566.1
XP_036015440.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040187.1 → NP_001035277.1  probable ATP-dependent RNA helicase DDX17 isoform 4

    See identical proteins and their annotated locations for NP_001035277.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 4).
    Source sequence(s)
    BC096036, CX220180
    Consensus CDS
    CCDS88805.1
    UniProtKB/Swiss-Prot
    Q501J6, Q6P5G1, Q8BIN2
    Related
    ENSMUSP00000155307.2, ENSMUST00000229877.2
    Conserved Domains (1) summary
    cl26939
    Location:32 → 500
    DEXDc; DEAD-like helicases superfamily

  2. NM_152806.3 → NP_690019.2  probable ATP-dependent RNA helicase DDX17 isoform 3

    See identical proteins and their annotated locations for NP_690019.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks most of the exons in the coding region, compared to transcript variant 1. The resulting protein (isoform 3) is much shorter with a different N-terminus when compared to isoform 1.
    Source sequence(s)
    BC038378, CD350507, CX220180
    UniProtKB/TrEMBL
    Q3U6Y5, Q8K392
    Conserved Domains (1) summary
    cd00079
    Location:22 → 60
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

  3. NM_199079.2 → NP_951061.1  probable ATP-dependent RNA helicase DDX17 isoform 2

    See identical proteins and their annotated locations for NP_951061.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two coding region segments, uses a different splice site in the 3' coding region, and contains a distinct 3' UTR, compared to transcript variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC117806
    Consensus CDS
    CCDS88804.1
    UniProtKB/TrEMBL
    Q3TU25
    Related
    ENSMUSP00000155737.2, ENSMUST00000229431.2
    Conserved Domains (1) summary
    cl26939
    Location:32 → 403
    DEXDc; DEAD-like helicases superfamily

  4. NM_199080.2 → NP_951062.1  probable ATP-dependent RNA helicase DDX17 isoform 1

    See identical proteins and their annotated locations for NP_951062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AK152831, BC038378, BC096036, CX220180
    Consensus CDS
    CCDS27643.1
    UniProtKB/TrEMBL
    Q3U741
    Related
    ENSMUSP00000055535.7, ENSMUST00000054014.9
    Conserved Domains (1) summary
    cl26939
    Location:32 → 502
    DEXDc; DEAD-like helicases superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79411897..79430976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159547.1 → XP_036015440.1  probable ATP-dependent RNA helicase DDX17 isoform X2

    Conserved Domains (1) summary
    PTZ00110
    Location:1 → 226
    PTZ00110; helicase; Provisional

  2. XM_030248706.1 → XP_030104566.1  probable ATP-dependent RNA helicase DDX17 isoform X1

    Conserved Domains (1) summary
    PTZ00110
    Location:1 → 228
    PTZ00110; helicase; Provisional

RNA

  1. XR_004938863.1 RNA Sequence

  2. XR_001781563.3 RNA Sequence

  3. XR_004938862.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q501J6.1 GenPept UniProtKB/Swiss-Prot:Q501J6

Gene LinkOut

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