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Ctnnbip1 catenin beta interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 67087, updated on 23-Jun-2021

Summary

Official Symbol
Ctnnbip1provided by MGI
Official Full Name
catenin beta interacting protein 1provided by MGI
Primary source
MGI:MGI:1915756
See related
Ensembl:ENSMUSG00000028988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IC; Catn; Icat; AW457332; Catnbip1; 1110008O09Rik; 2310001I19Rik
Expression
Ubiquitous expression in CNS E18 (RPKM 19.3), whole brain E14.5 (RPKM 17.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ctnnbip1 in Genome Data Viewer
Location:
4; 4 E2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149602698..149650894)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149518241..149566437)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (148892350..148940546)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene nicotinamide nucleotide adenylyltransferase 1 Neighboring gene leucine zipper and CTNNBIP1 domain containing Neighboring gene predicted gene, 24381 Neighboring gene microRNA 5616 Neighboring gene calsyntenin 1 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Neighboring gene microRNA 7023

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables armadillo repeat domain binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription initiation from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vascular permeability involved in acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of beta-catenin destruction complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of beta-catenin destruction complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
beta-catenin-interacting protein 1
Names
inhibitor of beta-catenin and Tcf-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001141930.1NP_001135402.1  beta-catenin-interacting protein 1

    See identical proteins and their annotated locations for NP_001135402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK003595, AK048258, BQ031304, BQ043263
    Consensus CDS
    CCDS38975.1
    UniProtKB/Swiss-Prot
    Q9JJN6
    Related
    ENSMUSP00000101317.2, ENSMUST00000105692.2
    Conserved Domains (1) summary
    pfam06384
    Location:179
    ICAT; Beta-catenin-interacting protein ICAT
  2. NM_023465.4NP_075954.1  beta-catenin-interacting protein 1

    See identical proteins and their annotated locations for NP_075954.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK036181, BQ031304
    Consensus CDS
    CCDS38975.1
    UniProtKB/Swiss-Prot
    Q9JJN6
    Related
    ENSMUSP00000030839.7, ENSMUST00000030839.13
    Conserved Domains (1) summary
    pfam06384
    Location:179
    ICAT; Beta-catenin-interacting protein ICAT

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    149602698..149650894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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