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Tomm34 translocase of outer mitochondrial membrane 34 [ Mus musculus (house mouse) ]

Gene ID: 67145, updated on 5-Mar-2024

Summary

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Official Symbol
Tomm34provided by MGI
Official Full Name
translocase of outer mitochondrial membrane 34provided by MGI
Primary source
MGI:MGI:1914395
See related
Ensembl:ENSMUSG00000018322 AllianceGenome:MGI:1914395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TOM34; 2610100K07Rik
Summary
Predicted to enable heat shock protein binding activity. Predicted to be involved in protein targeting to mitochondrion. Located in mitochondrion. Is expressed in dorsal root ganglion; glossopharyngeal ganglion; olfactory epithelium; thymus primordium; and trigeminal ganglion. Orthologous to human TOMM34 (translocase of outer mitochondrial membrane 34). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 25.7), thymus adult (RPKM 24.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H3; 2 84.6 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163895458..163913168, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164053538..164071178, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3417 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Neighboring gene poly(A) binding protein, cytoplasmic 1-like Neighboring gene STARR-positive B cell enhancer ABC_E10160 Neighboring gene STARR-positive B cell enhancer ABC_E6014 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:163910112-163910326 Neighboring gene serine/threonine kinase 4 Neighboring gene STARR-positive B cell enhancer mm9_chr2:163954265-163954566 Neighboring gene K+ voltage-gated channel, subfamily S, 1 Neighboring gene predicted gene, 53202

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of Tom34 splicing isoforms in mouse testis and knockout of Tom34 in mice. Terada K, et al. J Biochem, 2003 May. PMID 12801914
  2. RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Lo JC, et al. PLoS Genet, 2012. PMID 23055941, Free PMC Article
  3. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein targeting to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial import receptor subunit TOM34
Names
translocase of outer membrane 34 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291155.1 → NP_001278084.1  mitochondrial import receptor subunit TOM34 isoform a

    See identical proteins and their annotated locations for NP_001278084.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tom34a) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant Tom34b. The encoded isoform (a, also known as Tomm34a) has a distinct N-terminus and is the same length as isoform b.
    Source sequence(s)
    AK017699, BB869739, BM937584
    Consensus CDS
    CCDS71187.1
    UniProtKB/Swiss-Prot
    A2A5N5, A2A5N6, Q3THD0, Q812F1, Q812F2, Q9CYG7, Q9D059
    Related
    ENSMUSP00000105010.4, ENSMUST00000109384.10
    Conserved Domains (3) summary
    sd00006
    Location:193 → 221
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:229 → 260
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:192 → 257
    TPR_11; TPR repeat

  2. NM_025996.5 → NP_080272.1  mitochondrial import receptor subunit TOM34 isoform b

    See identical proteins and their annotated locations for NP_080272.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (Tom34b) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant Tom34a. The encoded isoform (b, also known as Tomm34b) has a distinct N-terminus and is the same length as isoform a.
    Source sequence(s)
    AK011786, AK017699, BM937584, CX235437
    Consensus CDS
    CCDS17020.1
    UniProtKB/Swiss-Prot
    Q9CYG7
    Related
    ENSMUSP00000018466.4, ENSMUST00000018466.4
    Conserved Domains (2) summary
    TIGR00990
    Location:12 → 294
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:193 → 221
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    163895458..163913168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500067.2 → XP_006500130.1  mitochondrial import receptor subunit TOM34 isoform X1

    See identical proteins and their annotated locations for XP_006500130.1

    UniProtKB/Swiss-Prot
    Q9CYG7
    Conserved Domains (2) summary
    TIGR00990
    Location:12 → 294
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:193 → 221
    TPR; TPR repeat [structural motif]

RNA

  1. XR_374511.5 RNA Sequence

  2. XR_003953697.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CYG7.1 GenPept UniProtKB/Swiss-Prot:Q9CYG7

Gene LinkOut

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